Study Of Hypericum Attenuatum Choisy And Salvia Miltiorrhiza Extracts And Compatibility On Myocardial Ischemia In Mice

Objective:Discussion the protective effect of Hypericum attenuatum Choisy (H.attenuatum Choisy) and Salvia miltiorrhiza compatibility on Myocardial Ischemia in Mice, which provide the basis for the compatibility of the Chinese medicine.Methods:Mice were randomly divided into H.attenuatum Choisy extract group, Salvia miltiorrhiza extract group, H.attenuatum Choisy and Salvia miltiorrhiza ratio (1:1,1:2,2:1), model group, positive group, blank group, each group have ten rats. Drugs were diluted with an equal dose of normal saline. The model group and the blank group were fed with equivalent dosage of saline. The contents of CK and the LDH-L were detected. The level of SOD and MDA were investigated.Result:1. H.attenuatum Chosiy and Salvia miltiorrhiza compatibility ratio1:2group can significantly reduce the LDH-L, CK level, increased SOD activity, decreased MDA content(P<0.01).2. H.attenuatum Chosiy and Salvia miltiorrhiza compatibility ratio1:2group which can significantly prolong the time of myocardial ischemia mice’s hypoxia(P<0.01).Conclusion:Such as dose, the experimental conditions compared with the single herb, H.attenuatum Chosiy and the Salvia miltiorrhiza ratio1:2has apparent protective effect in mice of myocardial ischemia.