| Objective：To observe the mentor Zhou Yanfeng, director of clinical treatment ofchronic aplastic anemia, aplastic anemia recover Decoction joint stanozolol, Cyclosporin Atreatment of chronic aplastic anemia (aplastic megaloblasts, AA), clinical efficacy andexplore the mechanism of its efficacy, and provide a theoretical basis for the combinationof Chinese and Western treatment of chronic aplastic anemia.Methods：Meet the inclusion criteria,60cases of chronic aplastic anemia patientswere randomly divided into treatment and control groups, the treatment group30cases,depending on their specific TCM syndromes (can be divided into the kidney, kidney yang,yin and yang, two impaired recovery soup-based subtraction combined with stanozolol,cyclosporin A treatment in the virtual type three) dialectical medication; control group (30cases), pure stanozolol plus cyclosporine A treatment, The treatment for6months. Observethe clinical efficacy of TCM symptom improvement in peripheral blood cell counts,peripheral blood and bone marrow blast percentage, liver and kidney function before andafter the two groups of patients. Observe the changes of vascular endothelial growth factor(VEGF) in two groups of patients before and after treatment, randomly selected from theserum of10cases of blood donors and blood donation station in the blood of those whocarried out the detection of vascular endothelial growth factor (VEGF), to enhance thecomparative effectiveness.Results：The clinical observations, treatment group TCM symptom of the overallefficacy of the total efficiency (clinical cure+cured+)83.33%, significantly better thanthe control group, the total efficiency of50%between the two there was a significantdifference (P <0.05); the treatment group of TCM symptom score improved significantly, significantly better than the control group (P <0.05); peripheral blood picture (WBC, HB,PLT count and WBC category): Before treatment, no significant differences ((P>0.05)after treatment in both groups increased, but the observation group increased significantlybetween the two there are significant differences (P <0.05); After treatment, significantimprovement in bone marrow before treatment, bone marrow efficiency count increasedsignificantly significant difference (P <0.05); two groups no significant changes observedin patients with liver and kidney function in two groups after treatment, and no significantdifferences ((P>0.05). experimental results show that the treatment group and controlgroup peripheral blood VEGF levels than before treatment was significantly improvedcompared with the control group were significantly different (P <0.05).Conclusion：1.The clinical study confirmed aplastic Anemia Recover Yuan Qi Tangjoint stanozolol, Cyclosporin A treatment of chronic aplastic anemia patients can beeffectively improved the clinical symptoms (mainly Chinese medicine symptom) andperipheral blood, bone marrow, liver no significant renal damage.Experimental study of found aplastic recovery soup can significantly improve thelevel of chronic aplastic anemia in patients with in vivo expression of VEGF. |
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