Expression And Clinical Significance Of LASP1and VEGF-C In Cervical Carcinoma

Objective To study expression and significance of actin-binding scaffolding protein LASP1and vascular endothelial growth factor C (VEGF-C)in cervical cancer tissue and to explore LASPlprotien and VEGF-C in promoting tumor cell proliferation and migration.Methods:1. To detect LASP1and VEGF-C expression in normal cervical cases, CIN and cervical carcinoma cases by immunohistochemical staining method.Result:1. The positive expression rate of LASP1protien in the cervical carcinoma, CIN and normal cervical cases were51.5%,20%,10%respectively; LASP1positive expression had a signigicant difference between cervical cancer and normal cervical,CIN and cervical cancer;2. The positive expression rate of VEGF-C protien in the cervical carcinoma, CIN and normal cervical cases were57.6%,26.7%,10%;the difference expression of VEGF-C were signigicant between cervical cancer and normal cervical.3. The positive expression of LASP1and VEGF-C in cervical carcinoma were related to lymph node metastasis and clinical stage,but were no related to patient age,pathological type,differentiation,clinical stage and myometrial invasion depth.4. The positive expression of LASP1in cervical cytoplasm were positively related to the positive expression of VEGF-C.5. The both positive expression rate of LASP1and VEGF-C in cervical carcinoma with the lymphatic transfer60%, while the both negative expression rate in the group of cervical carcinoma with the lymphatic transfer9.0%,there were significantly difference (P<0.05). The both positive expression of LASP1and VEGF-C in cervical carcinoma were positively related with the lymphatic transferConclusions:1.LASP1and VEGF-C play a role in cervical cancer pathogenesis. 2. LASP1and VEGF-C are playing a promoting and synergetic role in the pathogenesis of cervical cancer.