Clinical Research On Tangxiao Decoction Combined With Lifestyle Intervene On The Overweight And Obese IGT Patients With Phlegm-Dampness Constitution

Object i ve:Through the investigation of the influence of Tangxiao Decoction combined with lifestyle intervence on several indexes such as weight, blood glucose, blood lipid, blood pressure and insulin action index among the overweight and obese impaired glucose tolerance patients with phlegm-dampness constitution, this research is intended to evaluate its clinical curative effect and discover its possible underlying mechanism in the hope of assessing the effect of integrated traditional Chinese medicine therapy in the field of diabetes prevention and cure, which could provide evidence based medicine for the intervention of traditional Chinese medicine therapy in the cure of IGT.Methods:A prospective randomized clinical study method is applied. Screen the overweight and obese IGT out-patients and hospitalized patients from the Shiyan People’s Hospital, then subjects with IGT diagnose would then enter a one month wash-out period. At the end of the wash-out period, the patients were given a secondary oral glucose tolerance test. If they were still met with the inclusion criteria and beyond the exclusion criteria, they would be included in the trial after signing the informed consent. The patients were divided into treatment group and control group randomly. The control group only received routine lifestyle intervention; while the treatment group received routine lifestyle intervention plus Chinese medicine (Tangxiao Decoction). After12weeks of intervence on both groups, the main outcome measures are as follows:the constitution score, body mass index, waist-hip ratio, blood glucose, blood lipid, blood pressure, insulin action index etc. Results:1. Comparative efficacy of blood glucose:the effective rate of the treatment group was66.7%, the control group was40.0%, the treatment group showed significant difference in statistics compared with the control group (P <0.05)2. Comparison of constitution score:the effective rate of treatment group was73.3%, the control group was36.7%, the difference between the two groups was significant (P<0.01)3. Other testing index:The body mass index, fasting insulin levels, insulin action index, insulin resistance index, total cholesterol, low density lipoprotein of the treatment group were obviously improved after the treatment (P<0.01), which showed significant difference in statistics compared with the control group after treatment (P<0.05). The waist-hip ratio of the treatment group were obviously decreased after the treatment (P<0.05), while there was no significant difference between the two groups (P>0.05). After the treatment, there was no significant discrimination among blood pressure, triglyceride and high density lipoprotein of the treatment group compared with those before treatment(P>0.05); furthermore there was no significant difference between the two groups (P>0.05). After the treatment, we found that the body mass index and waist-hip ratio of the control group were significantly decreased(P<0.01), there was no significant discrimination in remaining indicators compared with those before treatment (P>0.05).Conelusion:Tangxiao Decoction combined with lifestyle intervention could effectively improve the unhealthy constitution of overweight and obese IGT patients with phlegm-dampness constitution, decrease the patient’s level of body weight and blood glucose, regulate the disorder of blood lipid and relieve the insulin resistance. It is a more effective therapy than normal lifestyle intervention and is worth further investigation.