| Objective:Observe the change of white blood cells on RA patients who take methotrexate3months, and research control of the disease activity. Set up the system about the contrast that the effect of methotrexate with cake-separated mild moxibustion therapy RA and pure using methotrexate therapy RA. Observe WBC to the effects of the RA patients who use cake-separated mild moxibustion and methotrexate.Get the principle of cake-separated mild moxibustion rising the WBC,and provide theoretical and experimental basis of cake-separated mild moxibustion participating in leukopenia disease caused by immune preparations.Methods:Clinical data:In June2010-June2011, all60cases come from patients in wuhan hospital of traditional chinese medicine, who get a normal WBC,60cases were randomly divided into2groups:The control group were treated with MTX. The treatment group were treated with the same treatment as the control group, and cake-separated mild moxibustion was added.therapeutic method:a. MTX group (The control group)30cases, Give MTX10mg, weekly1times oral, continuous oral12weeks. B. MTX+ cake-separated mild moxibustion (The treatment group)30cases, give the same treatment as the control group, and cake-separated mild moxibustion was added. Treatment after12weeks observe the curative effect. If patients with severe pain and can’t stand it, Loxoprofen Sodium discretion take temporary60mg, every time, three times a day, stop taking when the pain reduced. In addition, don’t give any other traditional related with the disease.Observation index:a. Symptoms and signs:joint tenderness number and tenderness index, joint swelling number and its swelling index, morning stiffness time, average grip, visual analog scale (VAS), disease activity score (the doctors and patients), HAQ index, DAS28, etc.; b. joint imaging:hands, feet, knees X piece of image; c. laboratory index:rheumatoid factor, blood sedimentation, c-c-reactie protein, the CCP, white blood count, the neutrophilic granulocyte count.Statistical methods:Use SPSS18.0package about data statistics and analysis, analysis by X-ray count material inspection, measuring material using t-test, statistical index data to x±s, P<0.05said differences with a statistical significance. Results:Two groups of patients (of60) in the guidance of drug use and the content of the jiu the gentle treatment group30people, the treatment group30people, all compliance is good, not to stop drug or stop the content of the jiu the gentle patients, no falls off, eliminate cases.The two groups of symptoms and signs to improve the situation is more:before treatment, the control group and the treatment group is the symptoms and signs, statistical analysis was statistically significant (P>0.05), comparable. After their corresponding system after treatment, the control group significant efficiency (improved obviously and powerfully) of60%, the treatment group significant efficiency (improved obviously and powerfully) of90%, two groups of the total curative effect after the statistical analysis, two groups of significant efficiency is statistically significant (P<0.05), cake-separated mild moxibustion with methotrexate treatment group of disease control of rheumatoid arthritis is better than pure using methotrexate group.Compare two groups of patients joint imaging:before treatment in the control group and the treatment group of abnormal joint imaging statistical analysis has no significant difference (P>0.05), after treatment, the control group and the treatment group two groups compared between groups, statistical analysis are statistically significant (P<0.05); In the control group and the treatment group before and after treatment in the group is joint imaging change statistical analysis indicates a statistically significant (P<0.05). Both groups that can improve the patient to a certain degree joint change, methotrexate with cake-separated mild moxibustion improvement of the joint group changes better effect.The two groups of patients laboratory indicators for comparison: before treatment, will the two groups of RF, ESR, CRP compares, statistical analysis difference was statistically significant (P>0.05) and how comparable; After treatment, will the two groups of RF, ESR, CRP numerical again is between groups, indicates a significant difference (P<0.05). The control group and the treatment group before and after treatment, RF ESR, CRP numerical comparison are significant difference (P<0.05). Explain methotrexate for the control of the laboratory parameters rheumatoid arthritis has an important significance, and when cake-separated mild moxibustion with methotrexate to use the control of the laboratory parameters is better.The two groups were white blood and neutrophil count are:before treatment, two groups of white blood and neutrophil count carries on the comparison, statistical analysis was not statistically significant difference (P>0.05), comparable; After treatment, the two groups of these carries on the comparison, statistical analysis significant difference (P<0.05), the difference was statistically significant. The control group before and after treatment is white blood cell count and neutrophil, statistical analysis significant difference (P<0.05), a statistical significance; Before and after treatment group is white blood count and neutrophil are, statistical analysis has no significant difference (P>0.05), no statistical significance. Explain methotrexate therapy rheumatoid joint adverse reactions caused one of white blood cells is reduced, and when using methotrexate with cake-separated mild moxibustion can control sticks to the probability of adverse reactions. Conclusion:This clinical trials observations suggest that the following: The methotrexate with cake-separated mild moxibustion therapy for patients with rheumatoid arthritis of symptoms and signs of improvement is better than pure using methotrexate group. The methotrexate with cake-separated mild moxibustion therapy rheumatoid arthritis treatment group of joint destruction of relief than simply using methotrexate group, even for some has been destroyed joints have certain repair function.The methotrexate with cake-separated mild moxibustion therapy rheumatoid arthritis laboratory index improvement is better than pure using methotrexate group.The methotrexate with cake-separated mild moxibustion therapy rheumatoid arthritis leukopenia and neutropenia has good control effect, effectively reduce the taking methotrexate appeared in the process of adverse reactions and side effects.Cake-separated mild moxibustion take methotrexate and cause of the white blood cells reduce disease of principle and the long-term outcome observation for rheumatoid arthritis mobility and the corresponding leukopenia situation related research. |
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