Clinical Observation On Promoting Patients With Chronic Hepatitis B E Antigen Seroconversion With The Fuzhengjiedu Therapy

Objective:This study through the observation method combined with the Fuzhengjiedu medicine of Western antiviral drugs treatment by simple western medicine antiviral drugs one year after treatment, serum e antigen continued positive patients with chronic hepatitis B e antigen seroconversion and HBeAg titer of circumstances, an objective assessment of the therapeutic effect of TCM righting detoxication treatment for chronic hepatitis B, and to explore the mechanism.Methods:Met the inclusion criteria of60cases of chronic hepatitis B treatment order randomly divided into control group (30cases) and the experimental group (30cases), the control group continued to be nucleoside drugs or interferon purely western medicine program for anti-viral treatment, the experimental group on the basis of the control group has the the righting detoxifying effect of traditional Chinese medicine-free fried particles oral day1, both groups continued treatment for24weeks. Observed in the course of treatment the two groups of patients with hepatitis B virus markers and quantitative HBV-DNA quantitative liver function and IFN-γ, IL-4laboratory target levels, and contrast the two groups, evaluation of traditional Chinese medicine righting assisted detoxification of chronic hepatitis B therapeutic effect.Results:Two groups of comprehensive effect comparison:patients the total effective rate was20.0%, the comparison group total effectiveness0.0%,two group total effectiveness after statistics analysis there are significant differences, P<0.05, patients curative effect than those in the control group.Two groups of TCM symptoms total score is:after treatment, the two groups of TCM symptoms total credit comparison, P<0.05, there is significant difference between the group than in the control groups.Two groups of liver function and HBV DNA quantitative comparison: the study of the liver function already complex observation is often, HBV DNA quantitative assessment of the patients have less than the minimum, after treatment two group of liver function and HBV DNA quantitative and treatment than before, P>0.05, no significant differences.Two groups of HBeAg drops the comparison of the degrees: treatment after12weeks, two groups of HBeAg drops degrees comparison, P>0.05, no significant differences;24weeks after treatment, the two groups of HBeAg drops degrees comparison, P<0.05, there is significant difference between the group than in the control groups.Two groups of IFN-γ and IL-4level of comparison:after treatment, the two groups of IFN-γ level is previous increased obviously, P<0.05, there is significant difference between the group than in control group; After treatment, the two groups of IL-4level is a slight decline before, P>0.05, no significant differences.Conclusion:Experimental group not only can improve the clinical symptoms of patients with chronic hepatitis B, but also can promote the T cells mediated the specificity of the immune response, promote e antigen turn Yin, improve CHB patients of e antigen serum conversion, shows that by the centralizer treatmen Chinese medicine therapy and chronic hepatitis B has certain advantages...