Environmental Factors Contribute To Low-/Non-Response To HBV Vaccine Among Twins

Objective:Considering twins as research object, to investigate the possible part ofenvironmental factors on low-,non-response to HBV vaccination.Methods:The Han andUygur twins who were born from1Mar,2009to31Dec,2010fully immunized accordingto the0-1-6program from five hospitals in Urumqi City. Through two steps of surveys,the researche was respectively obtained information including general situation of samples,parents’ health status, the pregnancy information of mother and birth status, birth, growthand feeding status within one year of age and so on. After twins’family members beinginformed and consented, twins were attended a medical examination when they were in1year of age with indicators for height, weight, head circumference and waistcircumference, peripheral venous blood samples HBV serological testing focusing onqualitative, quantitative anti-HBs detection after the completion of medical examination.Results:Difference of twins1and twins2vaccine response rate was not statisticallysignificant (2=0.118,P=0.914).In the twins group1and group2, the difference of maleand female in vaccine response rates respectively was also not statistically significant（2=0.1147，2=0.8456，P>0.05）, Han and Uygur vaccine response rates differencerespectively was not statistically significant（2=1.3956，2=3.1839，P>0.05）。We gotsome environmental factors which might be associated with low-,non-response afterhepatitis B vaccination: father smoking history, birth weight, weight gain withinone-year-old. OR of father smoking history was5.23(P<0.05), the difference wasstatistically significant; OR of low birth weight was2.44(P<0.05), the difference wasstatistically significant. OR of weight gain in one-year-old was0.45(P<0.05),thedifference was statistically significant; Conclusion:Firstly, low-,non-response rate intwins samples after hepatitis B vaccination in Urumqi was7percent（72/368）.Secondly,gender and tribe comparison’s difference was not statistically significant in terms ofvaccine response rate. Thirdly,factors having to do with low-,non-response after twinsvaccination consisted of father smoking history, low birth weight, weight gain within1year of age. Among these factors, father smoking and low birth weight were risk factors affecting occurrence of low-,non-response after hepatitis B vaccination. That was to say,the degree of low-,non-response’s risk infants whose fathers smoked after hepatitis Bvaccination had was5.23times than those children whose fathers did not smoke. Thedegree of low-,non-response’s risk low birth weight children after hepatitis B vaccinationhad was2.45times than normal birth weight children. Weight gain within1year of agewas a protective factor having impact on response after hepatitis B vaccination, namelybody weight each increased1Kg within1year of age, the risk of occurring response afterhepatitis B vaccination decreased by55%.The research suggested that attention should bepaid to improving perinatal and infant growth and development environment in order toheighten effective response rate after hepatitis B vaccination,. First of all, family membershad better quit smoking. Otherwise, effective measures should be put to preventoccurrence of low birth weight when babies were born. Through scientific feeding, thegrowth and development of infants is effectively promoted.