| ObjectiveTo know anti-HBs positive rate and antibody concentration of 20-49-year-old adults after HepB vaccination with different immunization strategies to compare the immune effects of different strategies.To know hepatitis B knowledge level,the status of HepB vaccination,the reasons for non-vaccination,the vaccination willingness of adults with no or unknown HepB vaccination history and related influencing factors among adults,which will provide scientific evidence for future adult HBV health education,development of adult HepB immunization strategies,and improvement of HepB vaccination willingness and coverage.MethodThe program data of "Research on adult Hepatitis B Vaccine Immunization Strategies" of the "11th Five-Year Plan" of National Science and Technology Project of Chinese CDC were used,the initial screening results of HBsAg,Anti-HBs,and Anti-HBc were all negative among 20-49 year-old adults were selected as research subjects to compare the immune effects of different HepB immunization schedules.The convenience sampling method was used in Beijing,Heilongjiang,and Gansu provinces to select 18-59-year-old adults to do questionnaire-based investigation to analyze hepatitis B knowledge level,the status of HepB vaccination,the reasons for non-vaccination,and the vaccination willingness of people with no or unknown vaccination history.ResultsHepB vaccination with different schedules,10?g HepB-HPY group vaccination with 0-1-2m,0-1-3m,0-1-6m,0-1-12m schedules,anti-HBs positive rate were respectively 71.57%,97.37%,100%,91.58%,GMC(mIU/mL)were 116.70,381.27,915.36,918.23,there were statitistical differrence for postive rate and GMC(?2=65.89,P<0.001;F=32.01,P<0.001).10?g HepB-CHO group vaccination with 0-1-3m,0-1-6m,0-1-12m,anti-HBs positive rate were 83.65%,88.55%,88.17%,GMC(mIU/mL)were 144.94.328.37,296.14,there were statitistical differrence for postive rate and GMC(?2=6.78,P=0.034;H=56.42,P<0.001).10?g HepB-SCY group with 0-1-2m,0-1-3m,0-1-6m,0-1-12m,anti-HBs positive rate were 81.33%,85.19%,87.07%,79.54%,GMC(mIU/mL)were 114.41,170.65,329.21,475.13,there were statitistical differrence for postive rate and GMC(?2=8.63,P=0.035;H=71.97,P<0.001),20?g HepB-SCY with 0-1-2m,0-1-3m,0-1-6m,the anti-HBs positive rate were 83.02%,100%,96.46%,GMC(mIU/mL)were 167.03,949.83,1688.67,there were statitistical differrence for postive rate and GMC(P<0.001;F=27.01,P<0.001).HepB vaccination with different types of HepB,10?g HepB-HPY,10?g HepB-SCY vaccination with 0-1-2m schedule,anti-HBs positive rates were 71.57%,81.34%,GMC(mIU/mL)were 116.70,114.41,there were no statitistical differrence for postive rate and GMC(?2=4.13,P=0.127;t=3.14,P=0.077);0-1-3m schedule group with 10?g HepB-HPY,10?g HepB-CHO,10?g HepB-SCY,the anti-HBs positive rate were 97.37%,83.65%,85.19%,GMC(mIU/mL)were 381.27,144.94,170.65,there were statitistical differrence for postive rate and GMC(?2=25.97,<0.001;H=35.22,P<0.001);0-1-6m schedule group with 10?g HepB-HPY,10?g HepB-CHO,10?g HepB-SCY,anti-HBs positive rates were 100%,88.55%,87.07%,GMC(mIU/mL)were 915.36,328.37,329.21,there were statitistical differrence for postive rate and GMC(?2=28.85,P<0.001;H=70.82,P<0.001);0-1-12m schedule group with 10?g HepB-HPY,10?g HepB-CHO and 10?g HepB-SCY,the anti-HBs positive rate were 91.58%,88.17%,79.54%,GMC(mIU/mL)were 918.23,296.14,475.13,there were statitistical differrence for postive rate and GMC(?2=12.13,P=0.002;H=28.07,P<0.001).HepB vaccination with different dosages,10?g HepB-SCY and 20?g HepB-SCY vaccination with 0-1-2m schedule,the anti-HBs positive rates were 81.34%,83.02%,GMC(mIU/mL)were 114.41,167.03,there were no statitistical differrence for postive rate and GMC(?2=0.07,P=0.789;t=-1.48,P=0.142);10?g HepB-SCY and 20?g HepB-SCY vaccination with 0-1-3m,the anti-HBs positive rates were 85.19%and 100%,GMC(mIU/mL)were 170.65,949.83,there were statitistic differrence for postive rate and GMC(?2=15.19,P<0.001;t=-8.56,P<0.001);10?g HepB-SCY and 20?g HepB-SCY vaccination with 0-1-6m,the anti-HBs positive rate were 87.07%,96.46%,GMC(mIU/mL)were 329.21 and 1688.67,there were statitistic differrence for postive rate and GMC(?2=8.20,P=0.004;t=-8.67,P<0.001).The average score of hepatitis B knowledge among respondents of three provinces was 8.07±2.64."Sharing syringes may be infected with HBV"(88.51%),"Mothers infected HBV may spread to their children"(85.48%),and "HBV can transmit by blood or blood products"(84.53%),correct rate of the three questions were high."Having meal with HBV infected person may get infected"(41.29%),"HBV Infection will definitely change to chronic and carry virus for life time"(12.82%),the correct rate of the two questions were low.Site,age,education level,occupation,with insurance or not and HBV infection among surrounding population were factors influencing hepatitis knowledge level.The HepB coverage was 48.61%,and full-series coverage was 28.85%.Site,age,address,education level,occupation,HBV infection among surrounding population,and hepatitis B knowledge scores were influencing factors of the HepB coverage,and HepB full-series coverage influencing factors included site,age,with insurance or not,HBV infection among surrounding population,and hepatitis B knowledge scores.Main reasons for people without HepB vaccination history were "I have a low risk of hepatitis B infection"(45.13%),"I am very healthy and do not need vaccination"(35.06%),"I am busy and have no time to vaccinate"(31.82%).The HepB vaccination willingness rate of those with no or unknown vaccination history was 72.48%.Site,gender,and with insurance or not were influencing factors for HepB vaccination willingness.ConclusionsAnti-HBs positive rates of 0-1-3m,0-1-6m,and 0-1-12m schedules are similar,and the high response rates in the 0-1-6m and 0-1-12m schedules have higher high response rates than 0-1-3m.Considering for vaccination compliance and convenience,0-1-6m should be the priority schedule.HepB-HPY has higher immune effect than HepB-SCY and HepB-CHO.20?g dose group has higher immune effect than 10?g,20?g should be the prority dosage.Adult HepB coverage and full-series coverage need to be further improved.Improving hepatitis B knowledge level and awareness of hepatitis B prevention and control can increase coverage.Gender and insurance are influencing factors of HepB vaccination willingness. |
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