A Preliminary Study Of Thyroid Microcarcinoma In Xinjiang

Objective: By studying clinical and pathological data of TMC and investigating theexpression of ER, Cyclin D1and E-calherin in PTMC, the aim is to explore the biologicalcharacteristics of TMC, and provide a theoretical basis to further improve the diagnosisand treatment of TMC. Methods: The clinical data of thyroid microcarcinoma wasanalyzed in retrospective from the first affiliated hospital of Xinjiang Medical University,from2002to2011, which was confirmed pathologically. Immuno-histochemistry wasused to detect ER, Cyclin D1and E-calherin in paraffin-embedded tissues of24cases ofnormal tissue,60cases of PTMC and76cases of PTC, and the expressions werecorrelated with clinicopathologic variables. Results:1. The detection rate (4.9%) ofthyroid microcarcinoma from2007to2011was significantly higher than the rate (1.0%)from the period of2002to2006. In thyroid microcarcinoma group, the cases (age≤45years) was accounting for53.24%(41/77), the cases was confirmed by fine-needleaspiration was accounting for17.64%(3/17), the cases was confirmed by frozen biopsywas accounting for70.58%(34/61), and lymph node metastasis rate was55.76%(34/61).The difference has statistical significance as compare to thyroid carcinoma a group(d>1cm).2. The expressions of ER in PTMC group, PTMCI group and PTMCII groupwere significantly higher than those in normal tissue, and the expressions in PTMC groupand PTMCI group were significantly lower than in PTC group. The positive expression ofER correlated significantly with age, tumor size, peplos and lymph node metastasis.3. Theexpressions of Cyclin D1in PTMC group and PTMCII group were significantly higherthan those in normal tissue.The positive expression of Cyclin D1correlated significantlywith age and tumor size. Cyclin D1had a positive correlation to the protein expression ofER.4. The expressions of E-calherin in PTMCII group were significantly lower than thosein normal tissue,and the expressions in PTMC group and PTMCI group were significantly higher than in PTC group. The positive expression of E-calherin correlated significantlywith age, carcinosis, lymph node metastasis and relapse. Conclusion:1. Biologicalcharacteristics of TMC are complex, and diagnosis and treatments are not standardized.2.ER may be used as an important indicator to judge the PTMC biological characteristics.3.When Cyclin D1expression raised, PTMC may have further increased the trend and beassociated with a poor prognosis. When expressions of ER and Cyclin D1raise at thesame time, prompt tumor status may be unstable, and increase the trend to continue todevelop even transfer.4. E-cadherin may be involved in invasion and metastasis of thyroidcancer, and the reduction in its expression indicates a poor prognosis. E-cadherin may beused as an important symbol to predict the PTMC biological behavior.