The Study Of Correlation Between Pulse Wave Velocity And Coronary Artery Disease

Abstract:To study the risk factors of coronary sclerosis disease (CHD), and the impact factors of pulse wave velocity (PWV), to explore the sensitivity of pulse wave velocity on predicting coronary sclerosis disease and the value to predict coronary atherosclerotic disease.Methods:416patients were chosen from department of Cardiology of the Second Hospital of Tianjin Medical University from March2011to December2011, men224cases (53.85%), women192cases (46.15%). According to the number of diseased vessels, coronary artery disease patients were divided into negative control group, the coronary angiography negative patients coronary artery stenosis<50%; positive group1:single vessel disease group; positive group2:double-vessel disease group; positive group3:left main or triple vessel disease group. Basic information of patients were detailed recorded.the patient’s gender, age, height, weight and other basic information, the next morning fasting blood levels of blood cholesterol, serum triglyceride, glucose, creatinine, and LDL-C, and pulse wave velocity detection.Results:107cases in416patients were exclude coronary artery disease after coronary artery angiography, the diagnosis of coronary artery disease in309people, single vessel disease in99cases in which positive group1coronary disease, positive group of two pairs of lesions in92cases, positive group3three lesions in118cases.416patients,224cases of males accounted for53.85%,192cases of women accounted for46.15%, age62.7±8.49years, height166±6.8cm,. The specific circumstances of each group of patients were as follows:negative group total107cases,39cases of males accounted for36.4%, female68cases accounted for63.6%, age58.3±9.4years, height164±8.0cm; positive group1, total of99cases,54cases of males accounted for54.5%, female45cases accounted for45.5%, age63.1±8.5years, height166±7.5cm, positive group2,92cases, male51cases accounted for55.4%, female41cases accounted for44.6%, age63.4±8.4years, height165±6.7cm; positive group3, total of118cases,80cases of males accounted for67.8%, female38cases accounted for32.2%, age65.9±8.1years, height168±6.3cm. All patients index was as follows:40.6%of smoking patients with169cases of the total patients, patients with diabetes mellitus23.8%of the total patients in99cases, blood glucose level was6.4±.4mmol/L,233cases of patients with hypertension56.0%of the total patients, systolic blood pressure was130.2±14.7mmHg, mean arterial blood pressure was97.7±11.5mmHg,416patients with triglyceride levels of1.83±0.77mmol/L, and cholesterol level was5.07±0.89mmol/L, LDL-C levels of3.0±0.6mmol/L, Bapwv level of1582±250cm/s, the ABI of1.1±0.1. The best cut-off for screening of CHD was1485.5cm/s, which predicted the presence of CHD with the sensitivity of65.7%, the specificity of60.7%Conclusions:Gender, age, body mass index, smoking, diabetes, blood glucose levels, hypertension, systolic blood pressure, mean arterial blood pressure, triglycerides, and Bapwv, and the ABI were the risk factors of coronary atherosclerosis disease. Age, systolic blood pressure, cholesterol, and high blood pressure were very important on influencing Bapwv. Patients with coronary atherosclerotic disease Bapwv were significantly higher than that of normal group, baPWV>1485.5cm/s can be regarded as sensitive index for screening CHD.