Value Of Ankle-brachial Pulse Wave Velocity In The Screening Of High-risk Patients For Coronary Artery Disease

Objective To study the variation characteristics of ankle-brachial pulse wave velocity (baPWV) in the patients with coronary heart disease (CHD) and evaluate its value for screening of CHD. Meanwhile, the issue of the cut-off for screening of CHD is to be discussed. Methods According to the result of the coronary angiography(CAG),which is the"gold standard"for CHD, the patients were divided into the CHD group and control group. All the patients received baPWV test. The variation characteristics of baPWV between the two groups were analysed and the efficacy of baPWV in the screening of CHD were evaluated by receiver operating characteristics (ROC) curve. The best cut-off was also determined by ROC curve. Results baPWV in CHD group were much higher than that in control group (1969.09±360.82 and 1583.37±333.36, respectively). There existed statistically significant difference between CHD group and control group (P=0.000). The area under curve of ROC (AUCROC) was used to further evaluate the screening efficacy of baPWV. The results showed that AUCROC was 0.821, which indicated that baPWV plays a valuable role in the screen of CHD. From the characteristic of ROC curve, the best cut-off for screening of CHD was 1650cm/s, which predicted the presence of CHD with the sensitivity of 80.92% , the specificity of 73.86% and Yueden's index of 0.548. Conclusions The baPWVs are significantly higher in the CHD group than those in the control group and the change of baPWV is contribute to the screening of CHD. It is abnormal for baPWV>1650cm/s and can be regarded as sensitive indexe for screening CHD .