The Study Of Quickly Repairing Rat Sciatic Nerve By Nerve Conduits Bonding Anastomosis

时胶液安全,不会进入神经断端,并且拉力强度大于传统缝合方法,满足手术需要。(3)制定出了相应的神经导管粘合吻合手术步骤。(4)坐骨神经切断后,神经自然回缩5.0±0.3mm,外径平均1.2±0.1mm左右,可供手术操作的有效长度长,分支少。因此,是适于本实验神经损伤修复得的适当模型。(5)神经导管粘合组吻合神经所需手术时间为1.0±0.5min,神经导管缝合组吻合神经所需手术时间为15.0±3.Omin,有显著差异(P<0.01)神经导管粘合法吻合大鼠坐骨神经速度上要远远快于神经导管缝合组。同时,两种手术方法术后坐骨神经指数、肌电图、小腿三头肌湿重恢复率、损伤神经周围炎症反应,组织学观察均可达到满意效果。结论本研究设计的神经导管和神经粘合吻合手术方式耗时明显短,操作简单,对手术条件要求低,达到了更快捷、更简便地粘合修复肢体大神经横断伤的目的。如果进一步研究顺利,有望于基层单位及战场等恶劣条件下使用。因此,这种粘合吻合神经方法是一种充满前景的神经吻合方法,但是,同时它也存在诸如：粘合剂毒性、硅胶神经导管不降解等缺点,需要后续进一步研究解决,在此仅作为对神经损伤修复方法的一种有益的探索。 the general state of the rat was also observed. After3months, test the SFI, EMI, crustriceps wet weight recovery rate and Inflammatory reaction around the injured nerve.And the nerve specimens were harvested and analyzed by light microscope andtransmission electron microscopic.ResultsA. The designed two-incision silicon nerve conduits were suitable for nerve conduitsbonding anastomosis.B. The amount of medical glu should be about20μL for the conduits of1.2mminternal diameter.C. Find a standard surgical procedure for nerve conduits bonding anastomosis.D. After severing the sciatic nerve, the average gap between the nerve ends was5.0±0.3mm, and the average external diameter of the nerve was1.2±0.1mm. Properoperation length and less branchs made the experimental animal model suitable fornerve anastomosis.E. The operation time for nerve conduits bonding anastomosis is about1.0±0.5minand nerve conduits suturing anastomosis15.0±3.0min. So, nerve conduits bondinganastomosis was much more faster than nerve conduits suturing anastomosis, and theresults of the SFI, EMI, crus triceps wet weight recovery rate and Inflammatory reactionare satisfying.ConclutionThe designed nerve conduits and bonding anastomosis is of time-saving, easier,less-depending on equipments. The bonding anastomosis appears to be a feasible andpromising ansatomosis method, which provide a benifical supplement to the suturinganastomosis on repairing the peripheral nerve injury.