Fastigial Nucleus Electrostimulation For Migraine Prevention

Background: Migraine is a common disease of frequent episodes, andimpact to patient health and social burden of diseaseseriously. Migraine acute treatment and prevention aredrug-based, but more side effects and poor compliance. Somesmall clinical trials showed that fastigial nucleus electrostimulation（FNS） for migraine have a significant effect and no adverse, and nowthere are no research reported of FNS for migraine prevention in globle.Objective： To assess the efficacy and safety of fastigial nucleuselectrostimulation for migraine prevention.Methods: A self-control study. In neurology outpatient of the SecondAffiliated Hospital of Chongqing Medical University, patients with migrainemeet the inclusion criteria were enrolled, and treated by FNS60minutesa day for3months, record the attack of migraine,the times of analgesic usedand the adverse events. In the course of the study, patients were telephonefollow-up weekly. The primary measure was change from baseline in meanmonthly migraine frequency. Secondary measures included efficacy of FNS,reductions in mean number of monthly migraine days, duration,severity,associated symptoms, times a month requiring rescue medication, and scoreof the Migraine Disability Assessment Test(MDAS). Adverse events were recorded.Results：79Patients with migraine were enrollded. Mean monthlymigraine frequency decreased significantly for patients after3monthstreatmen（t-4.56，p＜0.001）. The total effective rate was83%. The averagemonthly headache days was significantly decreased (-5.2, p <0.001);Headache duration changes were significantlydifferent (-15.1, p<0.01); The headache score of selfassessment changeswere significant different (p <0.01); The reduction of the analgesic useratio and times were significant differences (p <0.01);The improvement ofMDAS score was significant different (p <0.01);The changes ofall indicators（except MDAS） were statistically significant after the1stmonth treatment,and pairwise comparisons also statistically significant inthe1st month,2nd month and3rd month later. Adverse reactions have notbeen recorded in the course of the study.Conclusion：FNS is a safe and effective prevention for migraine andhas significantly effective after the1st month.It can significantly reduce themean monthly migraine frequency, number of monthly migraine days,duration,severity, associated symptoms, analgesic use and improve qualityof life significantly.