The Clinical Analysis Between Enlarged Perivascular Spaces And Cerebral Small Vessel Disease

ObjectivesTo investigate the association between enlarged perivascular spaces(EPVS)(including basal ganglia and centrum semiovale) and lacunarinfarction subtype, leukoaraiosis(LA).Methods110acute cerebral infarction patients were rucruited in ChongqingMedical University Second Affiliated Hospital of Neurology, fromDecember2010to August2011. According to the TOAST criteria, thepatients were divided into lacunar infarction group and large vesselarteriosclerosis group excluding cardiac cerebral infarction, other reasonsand unexplained cerebral infarction. Calculated the number of basal gangliaand centrum semiovale EPVS (0-4scores,0=none,4=>40) through brainmagnetic resonance imaging, and evaluated the scores of LA according tothe Fazekas score rating. Finally compared EPVS between lacunar infarctionand large artery atherosclerotic cerebral infarction, and assessed theassociations with vascular risk factors and LA.Results The110cases were recruited:40lacunar infarction group (36.6%), and70large artery atherosclerosis group (63.6%), in which there were62males(56.4%) and48females (43.6%), and the average age of67.55±11.44yearsold.(1) Correcting for cerebrovascular risk factors and LA, total EPVSwere associated with lacunar stroke (P<0.05) with multiple stepwiseregression;(2) Correcting for cerebrovascular risk factors and LA，basalganglia EPVS were associated with lacunar stroke (P<0.05) with binarylogistic regression，but centrum semiovale EPVS were not (P>0.05)；(2)Correcting for cerebrovascular risk factors，total and basal ganglia EPVSwere both associated with deep LA（P>0.05） with multiple regression，while not with periventricular leukoaraiosis (P>0.05).ConclusionsEnlarged perivascular spaces is particularly associated with lacunarinfarction and leukoaraiosis, which demonstrated enlarged perivascularspaces is potential signs of cerebral small vessel disease.