The Correlation Study Of H-type Hypertension And Acute Cerebral Infarction

Objective: To explore the relationship between H-type hypertension and acute cerebralinfarction, thus to provide the experimental and clinical evidence to prevent acute cerebralinfarction.Methods: The trail was based on case control study. Collected200cases of hospitalizedpatients with acute cerebral infarction(research group) in Chenzhou NO.1hospital fromseptember2009to September2011.other140hospitalized patients with transient ischemicattack(control group) were enrolled at the same period. The level of plasma homcysteine(Hcy) of every case was tested by enzyme-linked mmun-osorbent assay(ELISA) at thesecond or third day after onset. The data of the blood pressure、fasting blood sugar bloodlipid, and the gender、age、family history、other risk factors of all the patients wereregistered. According to the level of the plasma Hcy and the blood pressure, the researchgroup patients were allocated to four sub-groups: High Blood Pressure(SBP≥140mmHgand/or SDP≥90mmHg) High Hcy(≥10μmol/L)、 H-type Hypertension(High Bloodpressure with High Hcy) and Normal group. Statistics methods: single variable analysis dowith t-test, x2-test, multiple variable analysis do with non conditional logistic regression;Results:(1) The plasma Hcy level of male(20.28±8.98μmol/L) is higher than female(18.09±8.61μmol/L) across the two groups.(2) The plasma Hcy level of the patients inresearch group(18.15±8.73μmol/L) was higher than those in control group(12.24±4.33μmol/L),the differences were tatistically significant(P<0.01).(3) The incidence(40.5%) ofacute cerebral infarction in H-type Hypertension sub-group is high than the homocysteinemia(30.5%)(X2=11.54P＜0.01),than High blood Pressure sub-group(23.0%（)X2=4.56P＜0.05)，than the normal sub-group(6.0%)(X2=27.34, P＜0.01)(4) The mean plasmacylevel of the mild patients of acute cerebral infarction was(17.327.004μmol/L),the level ofthe moderate patients was (20.529.89μmol/L), and the level of the severity was (16.89.273μmol/L),the differences were not significant(P>0.05) by variance analysis.(5) By ult- ivariate logistic regression analysis, the independent risk factors of acute cerebral infarctionwere H-type hypertension [OR=3.27,95%CI(2.028~5.279)] and High Hcy[OR=2.2,95%CI(1.373～3.561)].Conclusions:1. H-type hypertension may have association with acute cerebral infarcti-on.2. The plasma Hcy level of the patients of acute cerebral infarction is higher than those oftransient ischemic attack．3. The plasma Hcy level is not correlated with the seve rities of acute cerebral infarction.4. H-type hypertension may be an independent risk of acute cerebral infarction.