Plasma HbA1C And Prognosis In Patients Undergoing Percutaneous Coronary Intervention

BackgroundCoronary atherosclerotic heart disease (CHD) is a major threat to human health. According to the statistics from WHO, CHD is the chief cause of death all over the world. At present, interventional therapy like PCI has become one of the most effective treatments for CHD. Compared with those without, the patients with diabetes suffer2to8time higher morbidity and mortality. In addition, the latter have greater risks for restenosis and major adverse cardiovascular events after interventional therapy. Glycosylated hemoglobin (HbAlc), which indicates how well blood sugar has been controlled, is closely related to the complications of diabetes. This study is aimed to investigate the relationship between the incidence of major adverse cardiovascular events and HbA1c level in CHD patients with and without diabetes mellitus who underwent PCI, thus providing evidence for clinical treatment.ObjectiveTo investigate the relationship between the incidence of major adverse cardiovascular events and HbA1c level in CHD patients with and without diabetes mellitus who underwent PCI, thus providing evidence for clinical treatment.MethodsThis research investigates292CHD patients who received PCI from January2007to December2009.A11of these patients are divided to3groups according the DM history and serum level of HbA1C.Group1(N=18):CHD patients who has DM disease and the serum level of HbA1C less than6.5%;Group2(N=45):CHD patients who has DM disease and the serum level of HbA1C more than6.5%;group3(N=229):CHD patients who do not have DM disease and the serum level of HbA1C less than6.5%.Compare the incidence rate of the MACE after PCI among three groups.The statistic method was adopted by the software SPSS17.0.Carry out data by using normal test. The results were measured by (X±S). First we compare correlation between the serum level of HbA1C and the incidence rate of MACE after PCI. The statistic data were analyzed with Chi-square tests(a=0.05). There were significances in statistics when P<0.05.ResultsThere was significant difference in MACE between NDM group and DM group24months after PCI. Further analysis shown that MACE rate was significantly higher in DM with poor-glycemic-control group than NDM group.ConclusionHigh HbAlc level (≧6.5%) may increase the long-term incidence of MACE in DM and CHD patients who underwent PCI.