The Correlation Analysis Of GA And HbA1c Level In Middle And Late Pregnancy Of GDM Patients With Neonatal Birth Weight

Gestational diabetes mellitus(GDM)is a type of diabetes with normal glucose metabolism before pregnancy and abnormal glucose metabolism during pregnancy.It is a common complication of pregnancy and can lead to increased morbidity or mortality of fetus or newborn.With the update of GDM diagnostic criteria,the incidence of GDM and macrosomia increased year by year,and clinical medical staff paid more and more attention to it.In this study,the correlation between the levels of glycosylated hemoglobin(HbA1c),glycosylated albumin(GA)and the birth weight of newborns was analyzed.Objective:By analyzing the correlation between gestational HbA1 c and GA levels and neonatal weight,the significance of HbA1 c and GA in guiding perinatal management of pregnant women was discussed,so as to provide reference for blood glucose control during pregnancy and prediction of macrosomia in GDM pregnant women.Methods:Retrospective analysis was performed on GDM pregnant women in our hospital during the period from December 2015 to December 2016.HbA1 c and GA were detected regularly after 28 weeks of gestation,and a total of 200 pregnant women with complete prenatal examination and full-term delivery records were selected,including 16 cases of giant infants and 184 cases of non-giant infants.HbA1 c and GA levels at 26,30,and 34 weeks of gestation were recorded,and the baby's weight was measured within 10 minutes after delivery.The correlation between HbA1 c and GA and neonatal weight was analyzed and evaluated,and the optimal critical value of both was further determined to predict the full-term macrosomia.Results:1.The neonatal weight of GDM pregnant women was significantly positively correlated with the HbAlc level at 26,30 and 34 weeks of gestation(r=0.616,P=0.001),(r=0.596,P=0.001),and(r=0.591,P=0.001).The neonatal weight delivered to GDM pregnant women was positively correlated with GA levels at 26,30 and 34 weeks of gestation(r=0.611,P=0.001),(r=0.620,P=0.001),and(r=0.613,P=0.001).2.The optimal cutoff values of HbA1 c at 26,30 and 34 weeks were 5.85%,5.75% and 5.95%.The optimal cutoff values of GA at 26,30 and 34 weeks of gestation for the prediction of term giant were 15.76%,16.95% and 16.94%.Conclusion:The detection of HbA1 c and GA levels in GDM pregnant women in the middle and late pregnancy can assist in the prediction of full-term delivery of macrosomia,provide guidance and reference for the control of blood glucose during pregnancy,and thereby reduce the incidence of perinatal complications such as macrosomia.