Analysis Of Relationship Between Ambulatory Blood Pressure With CAVI And ABI Change In High Blood Pressure With Type2diabetes Patients

Objective To investigate the analysis of relationship between24h ambulatory bloodpressure with arterial stiffness index: heart-ankle vascular index (cardio-ankle vascularindex, CAVI), ankle arm blood pressure index (ankle-brachial index, ABI) change inessential hypertension (essential hypertension,EH) with type2diabetes(type2diabetesmellitus, T2DM) patients.Methods90cases hospitalized patients were randomly divided into two groups.47cases consisted of high blood pressure group, and high biood pressure group associatedwith diabetes mellitus group including43cases.Every patient was measured by24-hourambulatory blood pressure monitor, CAVI, ABI and carotid ultrasound.Every25patients were randomly selected from the two groups.The levels of serummalondialdehyde(MDA) were measured using the thibabituric Acid.Result (1) Fasting blood glucose, C-reaction protein level, carotid plaques detection rateand serum malondialdehyde of EH+T2DM patients group were significantly higher thanthose of EH group respectively(P <0.05).(2) The average in each period of systolicblood pressure(SBP), pulse pressure (PP), systolic blood pressure load (SBP-L), earlymorning blood pressure, systolic blood pressure standard deviation (SBP-SD) andCAVI of EH+T2DM patients group were significantly higher and ABI and nighttimeblood pressure were significantly lower than those of EH group respectively(P <0.05). At the same time EH group in blood pressure curve of type was42.5%, EH+T2DMblood pressure curve of a type was23.3%.(3) CAVI and SBP, PP, nSBP-L,nDBP-L,nSBP-SD was positively related (P <0.05or P <0.01), R-ABI and SBP, dPP,SBP-L,dSBP-SD was negatively related (P <0.05or P <0.01). L-ABI and24hSBP,nSBP,24hPP, dPP, SBP-L, dSBP-SD was negatively related (P <0.05or P <0.01).Conclusion For diabetic patients with high blood pressure, the average systolic bloodpressure, pulse pressure load, systolic blood pressure and systolic blood pressureincreased that had a positively relation with CAVI and a negative correlation with ABI.At the same time the circadian rhythms weakened, early morning blood pressureincreased and oxidative stress reaction enhanced for diabetic patients with high bloodpressure. The above description in patients with diabetes mellitus complicated withhypertension that blood pressure control is poor, will promote the arterial stiffness andarterial hardening process.