| Objective:For the diagnosis of acute cerebral infarction, and traditional Chinese medicine differentiation of diseases for stroke patients with blood stasis syndrome in main and collateral channels, to injection of hydroxysafflor yellow A intravenous therapy, by observing the NIHSS scale, TCM syndrome integral, activity of daily living scale (ADL) Barthel index of effectiveness index, blood routine, blood coagulation in four, liver function, electrocardiogram and other safety indicators, evaluation of hydroxysafflor yellow A injection in treating acute cerebral infarction of the effectiveness and safetyMethods:1Clinical data Clinical observation of1clinical data of64cases from March to September in2010, in Traditional Chinese Medical Hospital of Hubei Provincial outpatient and hospitalization of patients with encephalopathy, western medicine for the diagnosis of the acute stage of cerebral infarction, apoplexy in traditional Chinese medicine as main and collateral channels, dialectical as the blood stasis syndrome cases. For patients using foundation treatment on the basis of the patients, according to the order in which each case of dispensing the drug, according to3:1ratio, were randomly divided into medication group48cases and control group with16cases. Pharmaceutical Group injected with hydroxysafflor yellow A,60mg daily; the control group with Xueshuantong injection, the day400mg. Two groups of drugs were added glucose5%250ml or0.9%250ml in sodium chloride injection, intravenous injection, once a day for14consecutive days, course of treatment, no introduction period. But shall not use any other effects of stroke disease curative effect evaluation of Chinese medicine pieces, chemical composition, medicine and anticoagulation defibrase, antiplatelet aggregation, improve cerebral vascular function of calcium antagonists and neurotrophic agents.2Curative effect observation of indicators efficacy indices including NIHSS scale score points, stroke, activity of daily living scale (ADL) Barthel index, observe and record time for a newly diagnosed on the first day,(7±1) day after dosing and (14±2) day after dosing, and the treatment group and the control group efficacy index statistical analysis. 3Safety indexes observed safety index including blood, four items of blood coagulation, liver function, renal function, fasting blood glucose, serum creatine kinase, urine, excrement routine, fecal occult blood examination, ECG, observe and record time for a newly diagnosed on the (1±2) day before dosing and (14±2) day after dosingResults:1TCM efficacy evaluation:after treatment of (7±1) day, medication group, clinical recovery in2cases, significant effective in0case, effective in31cases, the total efficiency was68%; the control group, clinical recovery in0case, significant effective in1case, effective in9cases, the total efficiency was62%. After treatment of (14±2) days, medication group, clinical recovery in3cases, significant effective in20cases, effective in24cases, the total efficiency was97%; the control group, clinical recovery in0case, significant effective in3cases, effective in11cases, the total efficiency was87%. Two recorded respectively after Ridit analysis, two groups had no significant difference (P>0.05), the syndrome of traditional Chinese medicine, injection of hydroxysafflor yellow A and efficacy of Xueshuantong efficacy without significant difference. 2Clinical outcome after treatment of NIHSS:(7±1) day, group of drug clinical recovery in0case, significant effective in2cases, effective in21cases, the total efficiency was48%; the control group, the clinical recovery0case, significant effective in1cases, effective in8cases, the total efficiency was56%.(14±2) days, group of drug clinical recovery in2cases, significant effective in16cases, effective in29cases, the total efficiency was98%; the control group, the clinical recovery1case, significant effective in5cases, effective in9cases, the total efficiency was94%. Two recorded respectively after Ridit analysis, two groups had no significant difference (P>0.05), the description of NIHSS, injection of hydroxysafflor yellow A and efficacy of Xueshuantong efficacy without significant difference.3Activities of daily living (ADL) Ability Scale (Barthel index) score:(7±1) day after treatment, group of drug clinical recovery in0cases, significant effective4cases, effective in19cases, the total efficiency was40%; control group, clinical recovery in0case, significant effective0case, effective in5cases, the total efficiency was31%.(14±2) days after treatment, group of drug clinical recovery in0case, significant effective19cases, effective in32cases, the total efficiency was75%; control group, clinical recovery in0case, significant effective1case, effective in8cases, the total efficiency was56%. Two records were tested by Ridit, comparison of the two groups had no significant difference (P>0.05). For activities of daily living (ADL) Ability Scale (Barthel index), injection of hydroxysafflor yellow A and efficacy of Xueshuantong efficacy without significant difference.4Safety inspection:inspection by t-test, the two groups before and after treatment, blood coagulation four, liver function, renal function, fasting blood glucose, serum creatine kinase, urine, excrement routine, fecal occult blood examination, ECG, there were no significant differences between them.Conclusions:Western medicine for the diagnosis of acute cerebral infarction, traditional Chinese medicine for stroke syndrome, blood stasis syndrome patients, injection of hydroxysafflor yellow A can improve the degree of neurological impairment, and the safety is good. |
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