The Value Of N-terminal Pro-brain Natriuretic Peptide In The Diagnosis And Treatment Of Patients With Chronic Heart Failure

Objective:The main aim of this study is to investigate the value of NT-proBNP indiagnosis and treatment of chronic heart failure.Methods:We selected95patientsadmitted in CCU for decompensated CHF and90normal controls.Comparing the level ofNT-proBNP between CHF group and normal controls,and the level in CHF group aftercuring one week.We compared NT-proBNP with LVEF and NYHA level.LVEF wasdetected with echocardiography.NYHA classification and standardised heart-failurescoring system were used to evaluate the clinical conditions of patients.Concentration ofNT-proBNP was determined with an ELISA assay.Statistic analysis was done withSPSS18.0software.Results:①The mean concentration of NT-proBNP in normal controlswas166.32±31.1ng/ml,and the distribution was normal.Plasma concentration ofNT-proBNP in CHF group was significantly higher than in normalcontrols(2802.5±418.0ng/ml vs.166.32±31.1ng/ml,P<0.001).②In CHF group,the level ofNT-proBNP was related positively to NYHA classification(r=0.245,P<0.05),the level inNYHA Ⅳwas higher than in NYHA Ⅱa ndⅢ (P<0.05).Level of NT-proBNP was relatednegatively to LVEF(r=-0.868,P<0.001).③In CHF groups,the level of NT-proBNP inNYHAⅡ、Ⅲ and Ⅳ were(783.5±59.6ng/ml、1459.4±106.5ng/ml、4689.2±231.6ng/ml)after curing one week(P was0.033、0.029and0.012).Conclusion:①L evel of NT-proBNPwas increased along with age.②It was higher in CHF group than in normal group,and thelevel of NT-proBNP was related positively to NYHA classification,related negatively toLVEF.③N T-proBNP had optimal value to diagnose and treat CHF.