The Clinical Value Of⁹⁹Tc^m-MIBI Imaging In Differential Diagnosis In Solitary Malignant And Benign Lesion Of Spine

Objective: To investigate the clinical value of the99mTc-MIBI imaging in differentialdiagnosis in solitary malignant and benign lesion of spine and to compare with the resultof⁹⁹Tc^m-MDP imaging. Methods:76patients （55malignant cases,21benign cases）studied with both⁹⁹Tc^m-MDP imaging and⁹⁹Tc^m-MIBI imaging performed30min afterinjection of740MBq within3days,Gaining both the diagnostic performance of⁹⁹Tc^m-MDP imaging and⁹⁹Tc^m-MIBI imaging and the best ratio to T/N Using ROC curve.Results: With76cases of solitary spinal lesions（55malignant cases） planar imaging of⁹⁹Tc^m-MDP sensitivity was89.09%, imaging of⁹⁹Tc^m-MDP SPECT/CT sensitivitywas80.00%, planar imaging of⁹⁹Tc^m-MIBI sensitivity was81.82%, imaging of⁹⁹Tc^m-MIBI SPECT/CT sensitivity was92.73%; the specificity of⁹⁹Tc^m-MIBI SPECTimaging（85.71%） was the highest in the four kinds imaging. In quantitative analysis of⁹⁹Tc^m-MIBI scan, the mean T/N ratio of malignant lesions （2.45±0.79，2.96±0.89） weresignificantly higher than that of benign counterparts （1.30±0.34,1.39±0.38，P<0.05）;butIn quantitative analysis of⁹⁹Tc^m-MDP scan, the mean T/N ratio of malignant lesions（2.61±0.90） and benign counterparts （2.37±0.59）were not significantly.the area underROC curve of⁹⁹Tc^m-MIBI imaging was the bigger than the that of⁹⁹Tc^m-MDP.Conclusion: The better diagnostic value in the⁹⁹Tc^m-MIBI imaging than⁹⁹Tc^m-MDPscintigraphy in single bone lesion of spine.