| Purpose: 99Tcm-N-NOET is a neutral lipophilic myocardial perfusion agent. Recently laboratory and clinical researches find that it can also be used as an tumor positive imaging agent and its concentrated degree is associated with cell metabolism and blood flow, so NOET can reflect the viability of tumor cell effectively and distinguish live tumor tissue with dead. The purpose of this study was to estimate the utility of NOET in the diagnosis of tumor.Method: We use 4 score system to perform naked-eye analysis according to the concentrated level. 0 score means no accumulation, 1 score small amount of accumulation, 2 score concentration, 3 score obvious concentration. 0-1 score is negative, 2-3 positive. The uptake ratios(the average pixel counts of tumor /the mean pixel counts of normal tissue at the mirror imaging of tumor, UR or T/N) were calculated in patients use the ROI technique. Some of them underwent MIBI imaging also. All patients operated after imaging during 2 weeks.Results: Among malignant lesions, NOET is concentrated on all thyroid and breast cancer patients and 5 out of 7 brain cancer patients. Among benign lesions, 2 out of 17 benign thyroid nodules, 1 case of benign breast lesion and 2 out of 17 benign intracranial occupying lesions including 1 case of meningoma of fibroblast type (polar hyperplasia) can concentrate NOET.Conclusion: This preliminary results indicate that NOET can be concentrated on malignant lesions, but it is few concentrated on benign nodules and the false positive cases are less than MIBI. So it may be a more suitable new tumor positive agent.
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