Comparison Of Efficacy And Safety Between Drug-eluting Stent And Conventional Therapies In Patients Of Coronary Heart Disease With In-stent Restenosis:a Meta-analysis

We performed a meta-analysis to compare therapeutic outcome/safety of drug-eluting stent (DES) and conventional in-stent restenosis (ISR) treatments. We browsed through large volume of clinical data by searching MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CCTR), and EBSCO databases.In this study,11RCTs,17NRCTs,6330patients and6662lesions were included. Clinical and coronary angiography follow-up for6-16months was included. The major outcomes were target lesion revascularization (TLR) and major adverse cardiac events (MACE). We found that DES showed advantage in TLR (OR=0.46;95%CI:0.34,0.62;P<0.00001), MACE (OR=0.51;95%CI:0.34,0.77; P=0.001), Late Lumen Loss (IV=-0.30;95%CI:-0.44,-0.15;P<0.0001), stenosis of lumen diameter (OR=-17.45;95%CI:-23.69,-11.21;P<0.00001) and restenosis (OR=0.26;95%CI:0.17,0.40;P<0.00001) over conventional ISR treatment. Regarding cardiac death (OR=0.80;95%CI:0.55,1.17;P=0.25), myocardial infarction (OR=1.00;95%CI:0.66,1.51;P=1.00) and late thrombosis (OR=0.70;95%CI:0.42,1.17;P=0.18), there was no significant difference between different treatments. We, therefore, concluded that in treating PCI-ISR, DES was more effective in reducing incidence of TLR, MACE and restenosis, and decreasing severity of late lumen loss/stenosis of lumen diameter compared with BMS, PTC A, ICBT, and Cutting Balloon treatments. There was no significant difference between DES and conventional therapy for ISR. As suggested by current statistical analysis, DES after ISR did not involve a higher incidence of cardiac death, myocardial infarction and thrombosis...