Study On The Correlation Between Colonoscopy Features,Pathology And TCM Syndrome Types Of87Cases Active Ulcerative Colitis

Objective:To research the relationship between TCM syndrome and age, disease duration, clinical symptoms, extent of disease, endoscopic features and pathological histology of active ulcerative colitis.In order to provide basis for the standardization of TCM syndrom differentiation.Materials and methods:87patients diagnosed as active ulcerative colitis by Fiberoptic Colonoscopy and biopsy from February2011to February2012were collected.Register the data of Age, gender, disease duration, clinical type, severity of disease, clinical manifestations, syndromes distribution, anatomical site, endoscopic features, the pathological manifestations and so on. Analyze of the relationship between TCM syndrome and the data above.Result:1.The ratio of male to female was1.29:1,The incidence was higher in Young people,The average age was44.84years old.Distribution of Syndrome type:Large intestine damp-heat syndrome of29cases,20cases of spleen-stomach qi deficiency,spleen-kidney yang deficiency syndrome of14cases, Intestinal stasis network syndrome12cases, liver stagnation and spleen deficiency of10cases,2cases of yin-blood deficiency. Chronic-relapsing forms was the most common clinical types, which has a number of60cases, early onset16cases,chronic persistent9cases, acute fulminant2cases. Duration of0-5years make the largest proportion(60cases). The Severity of desease was mainly mild.As the duration lengthening, the severity show aggravating tendency.The clinical manifestations were mainly of dirarrhea, mucus, bloody diarrhea and abdominal pain,associated with tenesmus, bloating,weight loss. The lesion mainly affect of rectum and sigmoid colon.By endoscopy,mucosal, vascular texture lesions, inflammatory exudate could be observed. Inflammatory cell infiltration, erosion ulcers, crypt abscesses, gland hyperplasia, granulation tissue and dysplasia could be observed by biopsy.2. TCM syndrome and the correlation of various factors:Young people mainly the large intestine damp-heat syndrome (54.35%), middle-aged to spleen-stomach deficiency (40.74%), the elderly, mainly in the spleen-kidney yang deficiency syndrome (42.86%) and spleen-stomach deficiency syndrome; Duration of0-5years mainly in the large intestine damp-heat syndrome and spleen-stomach deficiency,5to10years mainly in the spleen and stomach qi deficiency syndrome and spleen-kidney yang deficiency syndrome, over10years, mainly in spleen and kidney yang deficiency; The large intestine damp-heat syndrome, the spleen and stomach qi deficiency, spleen qi deficiency syndrome, liver stagnation and spleen deficiency syndrome, blood stasis and intestinal syndrome types showed diarrhea, mucus-bloody diarrhea, abdominal pain, Stasis intestinal syndrome type with abdominal pain, bloody stool-based, yin-blood deficiency certificates to the bloody stool-based。Lesions in the rectum, in straight sigmoid type large intestine mainly damp-heat syndrome and spleen-stomach qi deficiency, left colon, spleen and stomach qi deficiency and liver stagnation and spleen deficiency syndrome, extensive colon were more common in blood stasis and intestinal syndrome types, the entire colon was more common in the spleen-kidney yang deficiency syndrome and blood-stasis in intestinal syndrome type;Each type under the endoscopic visible to mucosal congestion and edema, diffuse needle-like ulcer lesions, vascular fuzzy texture。Damp-heat in the large intestine, spleen and stomach qi deficiency, liver stagnation and spleen deficiency syndrome mucosal surface erosion, purulent discharge attachment; Spleen-stomach qi deficiency syndrome seen mucosa rough particles easily bleeding, colon bag became dull; stasis in intestinal syndrome, Yin and Blood deficiency syndrome endoscopic visible mucosal rough granular easy to touch the bleeding, stasis in intestinal syndrome formation of polyps; Of TCM pathologic examination revealed acute and chronic inflammatory cell infiltration, large intestine damp-heat syndrome, the spleen and stomach qi deficiency pathological manifestations of the mucosal surface erosion, crypt abscesses, glands, spleen deficiency syndrome and liver stagnation and spleen deficiency syndrome, blood stasis in intestinal syndrome showed pathology visible mucosal surface erosion, crypt abscesses, gland hyperplasia, formation of granulation tissue; Yin-blood deficiency syndrome pathology see mucosal erosions, crypt abscesses, atypical hyperplasia, and granulation tissue formation. Conclusion:By researching TCM syndrome of the Active UC with age, disease duration, clinical symptoms, colonoscopy and histopathology, the results showed that there was a certain correlation。Endoscopic features and histopathology changes in some degree reflected the changes and progression of pathogenesis, the application of these indicators can be ulcerative colitis in Chinese medicine as a whole dialectical and local dialectical organic combination of applied clinical diagnosis and treatment.