The Expression And Clinical Significance Of HOXA10and Its Cofactors MEIS1, MEIS2Protein In Endometrial Adenocarcinoma

Objective: The protein level of HOXA10and its cofactors MEIS1,MEIS2aredetected in the endometrial adenocarcinoma and hyperplasia endometrial tissue andcompared in their expression differences.Their relationship with clinical cases ofendometrialadenocarcinoma will be observed.The significance of the biological behavior andclinicopathological significance in endometrial adenocarcinoma will be exploredabout HOXA10and its cofactors.Methods: The protein level of HOXA10and its cofactors will be detectedaccording to use immunohistochemical methods in the endometrial adenocarcinomaand hyperplasia endometrial tissue.Results:1. The protein level of HOXA10decresed in the endometrial adenocarcinoma andhyperplasia endometrial tissue.The protein level of HOXA10in the simplehyperplasia and the complexity of the proliferative phase compared with the normalproliferative phase have significant difference(P<0.05).The protein level of HOXA10in atypical hyperplasia and endometrial adenocarcinoma compared with the normal proliferative phase was significantly decreased,the difference of which wasstatistically significant(P<0.05).2. The protein level of MEIS1decresed in the endometrial adenocarcinoma andhyperplasia endometrial tissue.The protein level of MEIS1in the simple hyperplasiaand the complexity of the proliferative phase compared with the normal proliferativephase have significant difference(P<0.05).The protein level of MEIS1in atypicalhyperplasia and endometrial adenocarcinoma compared with the normal proliferativephase was significantly decreased,the difference of which was statisticallysignificant(P<0.05).3. The protein level of MEIS2decresed in the endometrial adenocarcinoma andhyperplasia endometrial tissue.The protein level of MEIS2in the simple hyperplasiaand the complexity of the proliferative phase compared with the normal proliferativephase have significant difference(P<0.05).However, The protein level of MEIS2inatypical hyperplasia and endometrial adenocarcinoma compared with the normalproliferative phase was significantly decreased,the difference of which wasstatistically significant(P<0.05).4.The correlation of HOXA10and its cofactors MEIS1,MEIS2protein is in differentendometrial hyperplasia and endometrial carcinoma.Conclusion: HOXA10is involved in the regulation of endometrial adenocarcinomaand promote the erosion of endometrial adenocarcinoma with its cofactors.