Research Clinical And Pathological Changes Of Chronic Hepatitis B Patients Infected Different HBV Genotypes

Objective:To investigate the relationship of ages,genders and nationalities in different genotypes chronic hepatitis B (CHB) patients, to compare the differences between different HBV genotypes and hepatic tissue damage degree, to explore the relationship between liver tissue pathology、HBV DNA levels and liver function of the chronic hepatitis B patients.Methods:Fluorescence quantitative polymerase chain reaction (PCR) instrument is used to test HBV DNA and real-time fluorescence quantitative polymerase chain reaction is used to test HBV genotypes in94cases of patients with CHB done liver biopsy.Results:B genotype give priority to,74.5%, C genotype accounted for25.5%at the group contained94cases. CHB patients HBV genotype has nothing to do with age and sex. Zhuang in C genotype in the share of the ratio is significantly higher and in hepatitis e antigen (HBeAg) positive patients is obviously lower than B genotype (P<0.05). CHB patients liver tissue pathology with degree of damage related to genotype B and C. The proportion of C genotype in heavier liver tissue inflammation and fibrosis degree is higher than B genotype,the difference have statistical significance (P<0.05).Liver tissue pathology with degree of damage related to liver function indexes (P<0.05), but has nothing to do with HBV DNA levels.Conclusion:HBV genotypes have B and C in this research of CHB patients, B genotype is the mainly distribution type, C genotype is the second, and has not seen the other types or mixed. The han nationality with B genotype primarily, zhuang criterion with C give priority to. B, C genotype in age, sex without difference. Compared with B genotype patients, C genotype patients with liver tissue inflammation and fibrosis degree are serious and prone to make serious liver damage and liver cancer and other adverse outcome.