Partial Pharmaceutical Technology And Efficacy Studies Of Isoflavone From Flos Puerariae And TCM "ZGSW" On Relieving Alcoholism

The raw material of this experimentation is Flos Puerariae which contains rich Saponin and isoflavone and be used as traditional medicine of our country, and to alleviate wine for a long time. According to the ancient medicine formula, Flos Puerariae was taken as the principal ingredient in order to manufacture a kind of capsule to be used to sober up, which is used Chinese herbal medicine "ZGSW" as accessories withdraw raw materials effective composition. What be mainly used for alleviating after the wine symptom, shorten the time to come to wine, adjust disease because of too much drinking.This experiment analyzed alcohol’s absorption path in the human body firstly and announced to public the harm of excess alcohol. This paper make a conclusion and comparison of the method of come to wine in home and abroad, give a new direction of the research of sober up. Give a summarize to the flower of Pueraria lobata and "ZGSW" in three main aspects: fundamentality form, main chemistry matter and pharmacology.The preparation craft of Flos Puerariae that take puerarin as standard substance, calculate the the extraction ratio of the isoflavone isolated from Flos Puerariae according to the valve of absorbency read in ultraviolet spectrophotometer. Investigated four factors: time, temperature and frequency of digestion, rature. According to single factor design of experiments the response surface of three the factors three horizontals test. The result show that the best one is the rature is1:27，temperature is76.3°C and the time is3.3hours. Drying method select to freeze drying.This experimentation doing research on the preparation of the effective composition of the compound prescribe Chinese herbal medicine"ZGSW" from lift craft and drying craft. According to the quadrature of four factors three horizontals tests, the best extract craft of F1and F3effective composition for join a solid-to-liquid ratio1:10super pure water,60℃water bath heating reflux withdraws a3hs and withdraws2times The best extract craft of F2effective composition is to join a solid-to-liquid ratio1:20super pure water,80℃water bath heating reflux withdraws a3hs and withdraws3times The best extract craft of F4effective composition is to join a solid-to-liquid ratio1:10super pure water,70℃water bath heating reflux withdraws a3hs and withdraws2times. Drying method select to freeze drying.Ultraviolet spectrophotometer helps to measurese the contents of isoflavone in the capsule is10.334mg/g. The result of the animal experiment shows that this capsule do not have acute toxicity, the UL of the small rat to this medicine≥22.5g/kg. The active of ADH in the blood of small rat along with the concentration of the sample, this result showing that the sample can help to increase the activity of ADH, and this action don’t have too much discrepancy to the female and male.