Research On The Prognostic Factors Of125Patients With Glioma

Glioma, originating from neural epithelium, is the most commonintracranial malignant tumor accounting for about60%of the primaryintracranial tumor. It is considered to be one of human malignant tumorwith worst prognosis. Presently, the application of the new technologygreatly promote the development of neurosurgery, however, fortreatment of glioma, especially high grade glioma, there is still not anybreakthrough. Since the1980s, one-year survival rate of multiformeglioblastoma (GBM) is not improving, and five-year survival rate is lessthan5%. Therefore, it is a difficult problem for neurosurgeons of all overthe world to prolong survival time and to improve the life quality ofpatients with glioma. The correlation factors of prognosis of glioma willbe discussed in this paper.Objective: To analyze the clinical data of the patients with glioma andreview literature, investigate the prognostic factors of glioma andrelevant clinical, pathological and genetic factors. Analyze the patient’ssurvival time and cumulative survival rate with different influentialfactors. It not only can help evaluate prognosis of the patients with glioma, but are also combined with the characteristics of the patients tomake an ideal individualized treatment. Therefore, it helps improve theprognosis of glioma patients.Method: The detailed clinical data from125human gliomas patientswho were treated in the Third Bethune Hospital of Jilin University fromMay2004to September2011are retrospectively analyzed. Describethe sum survival curve of each clinical factor using life table, andcompare the survive condition of them using Log-Rank test. Usemultiple factors COX regression analysis to evaluate the affection of thesurvival of those factors which have statistic significance by singlefactor analysis. Detect1year,3years,5years of survival rate with thelife table. All of these analysis are performed on SPSS18.0statisticalsoftware, and we set the standard as a statistical significance with bothsides P≤0.05.Results：1year,3years,5years of survival rate and the mediansurvival time among groups of age, pathologic grade, tumor resectiondegree, postoperative KPS score, preoperative tumor diameter, MGMTprotein expression have significant difference(P＜0.05)，but1year,3years,5years of survival rate and the median survival time betweengroups of gender, number of focal areas have no significant difference(P＞0.05). Age, pathologic grade, extent of tumor resection,postoperative KPS score, preoperative tumor diameter are dependentprognostic factors of human gliomas. KPS score≥70is goodindependent prognostic factor. The higher KPS score is, the betterprognosis of the patients is. Age≥40, pathological grade Ⅲ～Ⅳ,partial tumor resection, tumor diameter＞5cm are poor prognosisindependent factors. Postoperative comprehensive treatment, thesynchronous radiation and chemotherapy or simple radiation therapy,simple can prolong survival time in patients with High grade glioma, andimprove their prognosis.Conclusion: Age, pathological grade, extent of resection of the tumor,postoperative KPS score, preoperative tumor diameter are dependentprognostic factors of human gliomas. The prognosis of patients withpostoperative KPS score≥70are better. The prognosis of patients withage≥40, pathological grade Ⅲ～Ⅳ, partial resection of the tumor,preoperative tumor diameter＞5cm are worse. Postoperativecomprehensive treatment therapy can increase median survival time ofglioma patients with the high pathological grade and improve prognosis.