| Objective:As a modern prosthodontics way, Implant Denture provides patients with anew treatment experience. However, the main problem faced by the clinical isthe implant treatment cycle, which affects the quality of life of patients. How toshort the implant treatment cycle, accelerate the speed of osseointegration, andimprove implant early weight bearing is the goal of the majority of doctors. Aswe all know, the implant surface topography affects the speed and quality ofthe peri-implant osseointegration, and studies have shown that the implantsurfaces micron morphology can increase bone mechanical force, and improveimplant mechanical properties. At the same time, Micron morphologiespromote osteoblast adhesion, differentiation and extracellular matrix formationand mineralization. Nanotopography analogs cell growth environment, changesin cellular behavior, and promotes osteoblast adhesion, proliferation anddifferentiation, has a bionics effect. However, only a nano-structuremorphology is not enough to guarantee a solid osseointegration, micron-scalemorphology is still very important to the process of osseointegration. Somicro-nanotopography of implant surface is the focus of current research. Theexperiment by electrolytic etching method to deal with the implant surface,obtained a micro nanotopography and biomimetic surface, and to observe theprocess of early bone formation in vivo biomechanical experiments.Methods:We prepared three planting nests on one sides of the medial femoral in sixmongrel dogs, then planted EE,SLA and M groups implants and determinedthe initial stability. Animals were killed after3and6weeks. After removing the specimen block to do X-ray observation and biomechanical testing, andthen used the SEM to observe.Results:After three weeks, EE group implants has the maximum value of thepull-out strength（163.7±40.3N）,there were some differences with the M group（49.4±18.7N） and SLA group（141.7±18.5N）. EE and SLA groups, pulloutforce significantly higher than the M, has a statistically significant（P <0.05）.After six weeks, EE group implants has the maximum value of the pull-outstrength（381.7±56.1N）, there were great differences with the M group（209.3±38.0N） and SLA group（210.3±31.4N）. EE groups pullout forcesignificantly higher than the M and SLA groups, has a statistically significant（P <0.05）, SLA and M groups pullout force was not very different. The3week groups, maximum value of the pull-out strength compared with the6week groups,, with a significant difference, had statistically significant(P<0.05). Every group implant pullout force had the upward trend, but theEE group pullout force rose most significantly. Data analysis showed that: atthe6week, EE group implant had been very mature bone tissue, which hasshown the ability to promote early osteoblast.At3weeks, we observed the bone section of implant surface by SEM, the3groups of implants can be seen surface deposition and have different forms. Atlow magnification EE group implant surface adhered dense plaque bone tissue,and bone trabecular arranged in neat rows. At high magnification EE groupimplant surface adhered thick bone tissue, and didn’t have implant surfacestructure expose. AT low magnification the SLA group can be seen attached toa layer bone tissue of the implant surface, bone tissue thinner than EE groupimplant; At high magnification implant surfaces exposed portion of the porousstructure. AT low magnification a small amount of bone debris adhered on theM group implant surface, and most of the implant surface was exposed; At high magnification the implant surface had snowflake bone debris, irregulararrangement direction of the trabecular bone, and arranged parallel to thegroove on the implant surfaces. At6weeks the bone tissue on the implantsurface was more thick and dense than3weeks. The bone tissue of EE groupsurface was significantly thicker than the SLA and M groups; the new bonemass increased compared with the3weeks, the SLA group implant surfacebone tissue ordered uniform the porous structure of the implant surface wassignificantly reduced.At low magnification M group implant surface with a thinlayer of bone tissue, the amount of crushing bone debris was increased; At highmagnification we can see the parallel grooves of surface.Conclusion:By electrolytic etching method we can obtain a uniform of implantsurfaces with micro and nano structures bionic microtopography. This surfacecan promote early growth of bone, bone formation faster, shortening thecultivation of healing cycle, and provide a theoretical basis of the early loadingand immediate loading for the clinical... |
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