| The rhizome Chuanxiong set out in the"Shen Nong’s Classic of material medica", as a traditional staple of commonly used Chinese traditional medicine, the materia medica of many records, be calendar edition" Chinese Pharmacopoeia" included, for the Umbelliferae plant Ligusticum Chuanxiong Hort. dried rhizome of Ligusticum chuanxiong Hort, with promoting blood circulation of Qi, dispelling wind and relieving pain, blood gas delivery and headache to medicine. Through literature study, Chuanxiong pieces production market and the investigation of enterprise of Chuanxiong rhizome, classification, main chemical composition, as well as its complement to form pieces of fingerprint of Chuanxiong formula granule fingerprint do related research, the implementation of high quality for Chuanxiong rhizome and grade quality evaluation management system provides an experimental method and basis, this paper the research contents are as follows:1.From the literature shows that Chuanxiong has a long history,mainly product in Sichuan, lardge production, supply at home and abroad, in addition to Sichuan, and other areas planted, but production is small, less circulation in the country, more than self-production marketing, to clarify the origin and circulation of ancient and modern Chuanxiong, through literature, ancient tailor Chuanxiong quality is staggering, but the lack of a modern scientific basis. By farmers, herbal medicine market, and medicine production enterprise surveys, the existing the Chuanxiong commodity specifications standards for the two specifications, four levels Chuanxiong Pieces EC goods in the market based upon the sales, the failure to implement the grading and quality evaluation of higher prices for better quality management.2.Through the Chuanxiong road estate area and non road estate District herbal collection of different producing areas, processing Chuanxiong pieces of main chemical composition and the quality evaluation, the results showed that areas of Sichuan Chuanxiong pieces quality relatively actor, Jiangsu, Yunnan, Jiangxi, Gansu is poorer, consistent with the ancients to Sichuan Chuanxiong wins. At the same time, the traditional classification method and the modern evaluation methods are combined, the Tao estate District Pengzhou production base GAP Chuanxiong pieces divided into three grades, the results of different grade Chuanxiong rhizome has a certain quality differences.3. through on the fingerprint of Chuanxiong rhizome characteristics, developed the HPLC fingerprint evaluation method, and the similarity evaluation and clustering analysis of the regions of Pengzhou, Dujiangyan Sichuan, divided into a class, other regions of Jiangsu, Yunnan, Jiangxi, Gansu is divided into a class, combined with the evaluation results, to implement the origin classification, the Sichuan region is divided into a, divided into two provinces regions. To determine the origin of the divided pieces grade method.4.Through the complementary forms of Chuanxiong rhizome Chuanxiong formula granule main effective ingredient ferulic acid content determination and fingerprint research, developed the fingerprint evaluation method, accurate, reasonable, feasible, and can be used for the evaluation of its quality. Results of different manufacturers of Chuanxiong formula granule quality difference.In this paper, mainly from the above aspects Chuanxiong Pieces grade divided between the different levels of the main active chemical ingredients and their quality evaluation research, and provide a scientific basis and reference for the rational use and higher prices for better quality management of clinical Chuanxiong Pieces. |
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