Expressions Of COX-2and Survivin In Tumor Invasion And Metastasis Of Colon Cancer

Objective: To investigate the relationship between Cyclooxygenase-2(COX-2) andSurvivin and colon cancer, and to explore the possible mechanisms in the mutualrelationship between the invasion and metastasis in colon cancer.Methods: Using immunohistochemical staining106cases by surgical resection ofprimary colon cancer tissue and30cases of normal colonic mucosa tissue COX-2andSurvivin expression, statistical analysis of COX-2and Survivin expression and tumorclinicopathological characteristics. Explore the correlation between colon cancer.Results:(1) in colon cancer tissue COX-2and Survivin positive expression rate of71.7%and77.4%, compared with normal colonic mucosa tissue positive expressionrate of23.3%and26.7%, the differences were significant (P<0.05).(2) of COX-2expression and tumor invasion level,lymph node metastasis and Dukes stagein coloncancer was significantly positive correlation (P<0.05). And colon cancer patients byage, sex, histological type and tumor size no significant correlation (P>0.05). Survivinexpression was correlated with invasion process, lymph node metastasis and Dukesstage in colon cancer showed a significantly positive correlation (P<0.05), Survivinand patients with colon cancer and age, sex, histological type and tumor size werecorrelated (P>0.05).(3) found that the contrast related to colon cancer, COX-2andSurvivin expression of COX-2expression in colon cancer tissue with Survivinexpression has significant correlation (r=0.463, P=0.039). Related colon cancer bycomparing the lymph node metastasis and Dukes stage of COX-2and Survivinexpression found of COX-2and Survivin expression in colon cancer local invasionand lymphatic metastasis (P<0.05).Conclusion: COX-2and Survivin was highly expressed in colon cancer and there iscorrelation between expression of COX-2and Survivin and development of colon cancer.The expression of COX-2and Survivin was intereact mutually，and has relationswith invasion and lymph node metastasis in colon cancer. COX-2and Survivin canbe used as a predictor of colon cancer invasion, metastasis molecular biology index.