Clinical Retrospective Observation And Analysis Of Disseminated Intravascular Coagulation

Objective: With the application of domestic DIC diagnosis system,we try torevalue our diagnosis of the patients for the past three years. Then we try to make aretrospective analysis of the underlying diseases,clinical features and the laboratorytests，then try to discuss the correlations of the clinical outcomes of DIC and theunderlying diseases,the overt ISTH score and the treatments.Methods: Collect patients enrolled from First Hospital of Jilin University whowere diagnosed as DIC for the past three years. Choose the ones with enough clinicaldata who meet the domestic diagnostic criteria for DIC to revalue our diagnosis.Thentry to discuss the underlying disease,the clinical manifestations and laboratory testsincluding the platelet count (PLT), prothrombin time (PT), activated partialthromboplastin time (APTT), fibrinogen (FBG), fibrin degradation products (FDPs)and treatment of DIC. Then try to explain the correlations between the clinicaloutcomes of the disease with the underlying disease,the ISTH score and the teatments.Data were analyzed by SPSS16.0software, the enumeration data were analyzed bychi square test or Fisher’s exact test. For measurement data which do not meet thenormal distribution we choose rank test instead. P <0.05was considered statisticallysignificant.Results:1.There were111patients who were diagnosed as DIC for the past three years,50of these patients met the diagnostic criteria.There are a large number of people withinsufficient clinical data. The diagnosis of DIC still need to be improved.2.The most common etiology of DIC were malignant tumor and infection, with therate of48%and32%. Bleeding especially mild to moderate bleeding and organfailure were the most common clinical manifestations.3.The sensitivity of laboratory tests: PLT(92%）, FBG(80%), FDPs(70%), PT(70%),APTT(42%).The elongation of APTT was more common seen in the infectious group,while it was rare to be saw in the malignant tumor group. 4.We didn’t find the correlations between the clinical outcomes of the disease withthe underlying diseases,the ISTH score and the treatment measures.Conclusion:1.The diagnosis of DIC in our hospital still need to be improved.As doctors, weshould enhance the awareness of DIC and take relevant laboratory examination andtry to make an early and accurate diagnosis.2. The clinical features can be different among the underlying diseases types.3. DIC as a critical disease with high mortality,once discovered, the treatmentshould be taken actively.