| Background:thyroid cancer (thyroid carcinoma) is the most common thyroidcancer, accounting for about1%of systemic cancer. Its four kinds ofpathological types in papillary thyroid cancer (papillary thyroidcarcinoma, PTC) is the most common, the prognosis is good. Papillarythyroid cancer etiology has not yet fully understood, but studies show thatpeople at home and abroad SNPs (single nucleotide polymorphism, SNP)with PTC and its susceptibility to the development of molecular geneticmechanisms were positively correlated. PTC gene diagnosis andsusceptibility SNP screening will be aided diagnosis, screening andreliable evidence of PTC, the PTC-depth study SNP association betweensusceptibility to early diagnosis of patients on PTC guiding role, but alsoto be able to study cancer gene therapy basis.Objective:To investigate the forkhead box E1(FOXE1, fork head box E1), alsoknown as thyroid transcription factor-2gene polymorphisms andpapillary thyroid cancer susceptibilityMethods:A hospital-based case-control study design and analysis of papillarythyroid carcinoma with FOXE1gene polymorphism. Results:A cancer patients of different gender irradiation condition astatistically significant difference (χ~2=19.041, P <0.05); rs1867278allele frequencies between cases and control groups statisticallysignificant difference (χ~2=3.919, P <0.05), genotype frequenciesbetween the two groups no significant difference (χ~2=4.880, P>0.05);rs965513allele and genotype frequencies in the case group and controlgroup was not statistically significant (χ~2=0.215, P>0.05; χ~2=2.683,P>0.05).Conclusions:Rs1867278locus may be papillary thyroid cancer susceptibility loci;by the rs1867278, rs965513haplotypes composed with papillary thyroidcancer may be unrelated. |
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