| Purpose：To investigate the seroprevalence of aquaporin-4antibodies (AQP4-Ab) andanalyze the positive rate in patients with different clinic features in opticneuritis(ON),and observe the general clinical features of the cases with the positiveAQP4-Ab in serum, to find out related clinic factors contributing to diagnosis andprognostic evaluation of patients with ON.Methods：Collecting the clinical data of ninty-eight patients who were in-hospital inophthalmology of PLA from Sep.2010to Apr.2012. They all had been diagnosed ONaccording to diagnostic standard from Opticneuritis Study Group. All cases werescreened for serum AQP4-Ab and partial for antinuclear antibodies(ANAs),brain MRI,et al. And followed to divide them into different groups according to different clinicalfeatures, including single or bilateral eyes were attacked in first time,times of fall ill,positive or negative of ANAs, et al. Then to statistic and compare the positive rate ofAQP4-Ab in both groups respectively. At last, summarying the general clinical featuresof ON with AQP4-Ab in serum.Results：Among of all patients, the positive rate of AQP4-Ab was25.5%(25/98), and that infemale(31.9%) and the cases with pain in broken eye(35.3%) were higher obviouslythan in male(7.7%) and painless cases(14.9%) respectively. The positive rate were nosignificant differences between single ON(20.9%) and bilateral eyes ON(29.1%). The result was similar on onset between single eye(25%) and bilateral eyes(26.7%) at thesame time. The positive rate of ANAs was20.7%in87cases, and in which the positiverate of AQP4-Ab were significant difference between group with ANAs(72.2%) andgroup with no ANAs(13%)(P＜0.05, X2=23.4)..However, there were no significantdifferences between NMOSDs group(29.4%) and the counter-group(21.1%).Among ofthe25cases with in serum, the ratio of male to female was1：11.5and the average agaof onset was30.7years old, of which the seroprevalence rates of ANAs was59.1%(13/22). There were19cases(76.0%,19/25) whose the AQP4-Ab titer were1/10or1/100in serum. To the25cases, the rate of ON with pianess on the first attacked,bilateral ON, recurrent ON were72.0%(18/25),64.0%(16/25) and52.0%(13/25),respectively. There were16patients(94.1%,16/17) who had ever appeared the lowestvisual acuity(corrected) of＜0.1in the course of disease,and that was13patients(52%,13/25) on admission. Of which80%of patients without optic disc edemaand56.0%cases with delaying in time and droping in amplitude of VEP.Conclusions：The distribution of AQP4-Ab was significant related to ANAs in the patients withON， however it seems no correlation with attacted-eye number on onset or recurrent.Majority patients with seropositive of AQP4-Ab showed lower antibody titer and severevisual impairment. Who are female, accompanied eye pain and positive ANAs in serummay be clinical features to assessing ON development. |
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