Analysis Of Distribution And Drug Sensitivity Of Pathogens In Neonatal Bacterial Infection

Objective To monitor the distribution and drug sensitivity status of pathogens in neonatal bacterial infection and instruct clinical drug application.Methods From June2011to May2012,323cases of infectious diseases in newborns were collected throat swabs, umbilical secretions, sputum, blood, pustular fluid, gastric washing specimens,then the specimens were made germiculture, then the results of the distribution and drug sensitivity of pathogens were statistically analyzed.Results A total of184pathogens strains were isolated.94strains(51.1%) of the pathogens were Gram-negative bacilli,which were mainly Escherichia coll (39.4%), Klebsiella pneumoniae (28.7%) and Enterobacter cloacae (10.6%); Gram-postive cocci contained90strains(48.9%),which were mainly Staphylococcus aurens (26.7%), epidermis Staphylococcus (20.0%) and hemolytic Staphylococcus (12.2%). The most common pathogens of neonatal sepsis were Staphylococcus aureus, then in series Staphylococcus haemolyticus and Klebsiella pneumoniae.The imipenem, Amikacin, cefoperazone and sulbactam, piperacillin and tazobactam sensitive rates of Gram negative bacilli was97.3%,100%,77.8%,88.8%,respectively.The ceftriaxone, cefotaxime sensitive rates of Gram negative bacilli was below40.0%.The cefoperazone, cefuroxime sensitive rates of Gram negative bacilli was lower than25.0%.The piperacillin sensitive rate of Gram negative bacilli was below15.0%.The linezolid sensitive rate of Gram-positive bacteria was100%.The penicillin sensitive rate of Gram-positive bacteria was lower than15.0%.The vancomycin sensitive rate of Staphylococcus epidermidis was95.0%, while the teicoplanin sensitive rate of Staphylococcus epidermidis was93.8%.Conclusion The main pathogens of neonatal infectious disease is Gram-negative bacteria, which includes Escherichia coli and Klebsiella pneumoniae.Gram-positive pathogens consist of Staphylococcus aureus and Staphylococcus aureus. Different bacteria is isolated in different seasons and regions. The commonly used first-line and second-line antibiotics sensitive rates of bacteria are low, and selecting sensitive antibiotics is the key to effective treatment of neonatal infections.