Study On Two Types Of Gliomatosis Cerebri

Objective:There is little information on subtypes of GC. To evaluate the clinicopathologic and neuroimaging findings of GCs and to compare the clinical findings between Type1and Type2GCs.Methods:Clinical comparison between subtypes and Clinical analysis were performed. A total of13cases of GC were obtained from pathology file of Department of Neurosurgery. The diagnosis was based on magnetic resonance imaging findings and histological confirmation for all patients. Thirteen cases were classified into Type1and4were Type2based on the MR images.Results:The clinical manifestions of these13patients included headache(8/13) and seizure(3/13).Radiological examination revealed diffuse lesions infiltative process involving more than three cerebral lobes,a diagnosis of MRS should be considered. Histologically,13cases of GC were classified into low and high grade histologic grades by cytologic anaplasia. Low-grade GC was more common in Type1than Type2.Immunohistochemical and Ultramicrostructure results demonstrated that the infiltrating tumor cells were undifferentiated cells with astrocytic or oligodendroglial differentiation.Conclusions:Macroscopically, two types of primary Type1GC is the classical lesion in which there is a diffuse neoplastic growth and enlargement of the involved existing structure,without the formation of a circumscribed tumor mass at initial clinical presentation. Type2GC, which may develop from Type1, is associated with the presence, in addition to the diffuse lesion, of an obvious neoplastic mass at initial clinical presentation.GC have been distinguished Type1and2GCs are somewhat different in neuroimaging and pathologic features. Type1GC were undifferentiated cells with astrocytic common. Management of GC was based on magnetic resonance imaging findings and histological confirmation for patients.