Literature Analysis Of Reye Syndrome In China(1989-2012)

Objective: Reye syndrome (Reye syndrome, RS), also known as encepha-lopathy with visceral fat degeneration, is characterized by acute encephalopat-hy, hepatic disorders and progressive metabolic disturbance. It is mostly seenin6months to3years old infants and young children. The mortality rate ofReye syndrome is26%~43%according to data from other countries. In china,there has been more case reports of Reye syndrome over the years. In this artic–le, we analyzed the epidemiological characteristics, clinical treatment and pro-gnosis of Reye syndrome in China from1989to2012in order to shed lighton clinical treatment of Reye syndrome in China.Methods: We used Reye syndrome as keywords and searched paperspublished in1989-2012on China National Knowledge Internet(cnki) platform,wanfang database and weipu database. We collected390cases after incorrectcases were excluded. The390cases were divided into4groups according tothe time of disease occur:1989-1994group,1995-2000group,2001-2006group,2007-2012group. We compared the disease number, gender, averageage and recovery rate of the4groups.In those390patients,337cases were diagnosed and got effectivetreatment within24h after admission. We compared prognosis according toconsciousness disturbance, blood ammonia level. Prognosis outcomesincluded cured and uncured(uncured included death and patients with long-term sequelae). According to treatment regimens, the patients were dividedinto group A-G. All hospitalized patients received intracraninal pressurecorrection, maintaining water and electrolyte balance, correcting acid-basedisorders and support treatment, those of which was called conventionaltreatment. Group A:conventional treatment; Group B: conven-tionnal+anti-infection treatment; Group C:conventional+liver protection treat-ment; GroupD:conventional+fall blood ammonia treatment; Group E: conve-ntional, anti-infection and liver protection treatment; F group: normal+protect liver,fall blood ammonia treatment; Group G: conventional+protect liver, fallblood ammonia treatment+anti-infection treatment. We evaluate differenttreatment regimens according to different prognostic outcomes.SPSS18.0software was used to analyze data. It was regarded as statistically significant when P <0.05. T test was used to analyze measurement dataand X~2test was used to analyze categorical data.Results:1general situationReye syndrome incidence in1989-2012in China was on the top in1994-2006. However, the incidence decreased significantly since2007. Theratio of male to female was about1:0.79with no significant difference in allages. The average age appeared a rising trend in recent years. With Reyesyndrome being understand more widely, its cure rate increased significantly.2According to the clinical manifestation prognosis assessment2.1According to whether patients appeared deep coma for more than48h,patients were divided into two groups. Prognosis of patients with more than48h’s deep coma were poorer.2.2According to whether patients appeared repeated eclamptic, patients weredivided into two groups based on the prognosis. We found that patients whoappeared repeated eclamptic showed poorer prognosis.2.3According to the patient’s blood ammonia level, patients were divided intotwo groups: patients whose blood ammonia level were higher than or equal to300μg/dl and those whose blood ammonia level were less than300μg/dl. Wefound that patients whose ammonia level were higher than300μg/dl showedpoorer prognosis.3Different treatment prognosisNo obvious prognosis difference was found between Group A, group Bgroup C and group E patients (P>0.05). However, there were differencebetween these aforementioned groups and group D, F and G (P<0.05). Thecure rates were lower than the group D, F and G group. No obvious prognosis difference was found between Group D, F, G (P>0.05). According to variouscomparison of the prognosis of patients, it can be concluded that: in thetreatment of Reye syndrome, reducing intracraninal pressure, maintainingwater and electrolyte balance, correcting acid-base disorders and supporttreatment is widely used. Reducing blood ammonia treatment could improvethe prognosis while anti-infection and liver protection treatment had noobvious effect on disease prognosis.Conclusion: Reye syndrome has been attracting more and more attentionof clinic doctors. Its cure rate has been significantly increased. The averageonset age of Reye syndrome appears a rising trend in recent years. Theincidence began to decline since2007. In the clinical treatment, reducingintracraninal pressure, maintaining water and electrolyte balance, correctingacid-base balance disorders and support treatment is widely used. Reducingblood ammonia treatment has positive effects to improve its prognosis.