| Objective：To evaluate the clinical efficacy and safety of theprescription of Bushenqingre in treatment of chronic Idiopathicthrombocytopenic purpura,by compareing the changes of the plateletcount (Plt) and TCM symptoms quantify integral before and afterthe treatment, created by the two therapeutic schedules,thesimple Western medicine therapeutic schedule and the prescriptionof Bushenqingre with the Western medicine therapeutic schedule.Method：All the69patients whose were diagnosed as chronic idiopathicthrombocytopenic purpura, came from out-patient and in-patientdepartment of Hubei Provincial Hospital of TCM from March2011toMarch2012. Eventually33patients in the treatment group and32patients in the control group underwent the efficacy observationand safety evaluation.The treatment group（the therapeutic scheduleof combination of Chinese traditional and Western medicine）weretreated with the prescription of Bushenqingre and Western medicine,while the control group (purely Western medicine therapeuticschedule) be treated with Western medicine, in a total of24weeks.To observe the changes of TCM mainly symptoms quantify integral andplatelet count, and adverse reactions at the same time. SPSS19.0 was used to analyze test data and evaluate the efficacy and safetyof the prescription of Bushenqingre.Results：1. The TCM symptoms quantified integral. On the13th-week, nosignificant difference between the treatment group and the controlgroup was observed（P>0.05）. On the25th-week, the significantdifference was observed, between the treatment group and thecontrol group（P <0.01）.The treatment group was better than thecontrol group in improving TCM symptoms.2. The curative effect criterion of TCM syndromes. In thetreatment group,19cases were clinical cured,8marked asexcellence case,4was effective case, and2cases were inefficiencycases. The effective power was94%in the treatment group. In thecontrol group,8cases were clinical cured,17marked as excellencecase,5was effective case, while2cases were inefficiency cases.The effective power was94%in the control group. The differencebetween groups was statistically significant (P <0.05). Althoughthe two groups have the same efficiency, the clinical cured rateand excellent rate of the treatment group are higher than that ofthe control group. The treatment group was better than the controlgroup in terms of Chinese medicine efficacy.3. Platelet count. The platelet count of the treatment groupis always higher than that of the treatment group after treatment,and this gap between the two groups has a widening trend, in spiteof no significant difference observed between the treatment groupand the control group in the24-week observation.4. Western medicine therapeutic evaluation. In the treatmentgroup,4cases were excellence cases,15cases have good effect, 11cases were progressing, and3were inefficiency. The effectivepower was94%in the treatment group. In the control group,1casewere excellence cases,6cases have good effect,20cases wereprogressing, and5were inefficiency. The effective power was84%in the control group. The difference between groups wasstatistically significant（P<0.05）.The efficiency in the treatmentgroup was higher than that in control group. The treatment groupwas better than the control group in terms of Western medicinetherapeutic evaluation.5. Security aspects. The incidence rate of adverse reactions,such as liver dysfunction, in the treatment group is lower than thecontrol group. The treatment group was better than the control groupin terms of reduce drug side effects.Conclusion：The therapeutic schedule of combination of Chinese traditionaland Western medicine could elevate platelet count, ease thepatient’s symptoms, and reduce the side effects of western medicine.For the treatment of CITP, the therapeutic schedule could enhancethe efficiency and reduce the toxicity. The treatment group wasbetter than the control group in terms of curative effect. |
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