The Study Of HPSE And VEGF-C MRNA Expression With Invasiveness And Metastasis In Human Lung Cancer

Objective To study the expressions of HPSE and VEGF-C mRNA with invasiveness and metastasis in human lung cancer.METHODS The expression of HPSE and VEGF-C mRNA in65cases of lung cancer, adjacent tissues of cancer and normal tissues was tested by RT-PCR and analysed by clinico-pathological characteristics and prognosis of lung cancer.RESULTS The rate of expression of HPSE and VEGF-C mRNA in tumor tissues (55.4%and61.5%) was significantly higher than that in adjacent tissues of cancer (12.3%and15.4%) and normal tissues (3.1%and4.6%)(P<0.05); It was shown that HPSE and VEGF-C mRNA expression did significantly not correlate with the type and grade of the tumor (P>0.05);but it correlated with the clinical stage (95.5%、100.0%and34.9%、41.9%)(P<0.05) and survival time of the patients (92.0%、96.0%and33.3%、44.4%)(P<0.05).CONCLUSIONS The results suggested that there be overexpression of HPSE and VEGF-C mRNA in lung cancer tissues, and which perhaps participate in regulation of tumorigenesis, progression in lung cancer. The expression of HPSE and VEGF-C mRNA be used as an useful marker of the biological behavior of lung cancer and as an independent prognosis factor for the patients with lung cancer.