| BackgroundsIn recent years, as a metabolic disorder, the prevalence of diabetes mellitus (DM) is increasing year by year in developed and developing countries.Research shows that, patients with diabetes mellitus will appear a variety of acute and chronic complications in the natural course of the progress of the disease,and the disease can cause the structural change and dysfunction of the tissues and organs.For patients with diabetes mellitus,it is easy to combine different infection and infection can induced acute complications,which is one of the important causes of the death of diabetes mellitus and has extremely serious influence to the prognosis and life quality of those.Therefore, to explore the pathogenesis of diabetes complicated with infection and find a new and effective prevention and control measures has become an important research topic in the current.Immunity is the most important guard system which resists pathogen invades the body.It plays an important role in infection.Many scholars at home and abroad has been found that function defects of cell immunity and humoral immunity were really happened in the body of patients with diabetes mellitus,but the specific immune changes in the body of patients with this disease still need further research.ObjectiveTo explore the relationship between type2diabetic patients complicated with infection and change of immune function in the body, provide theoretical support for clinical treatment of diabetes complicated with infection.Subjects and MethodsAccording to the diagnostic criteria for diabetes released in1999by the WHO, type2diabetes mellitus group selected were diagnosed type2diabetes, the duration of diabetes was ((7-12)) years and the age was (60-75) years old. According to whether complicated with infection,the patients with type2diabetes mellitus selected were divided into diabetes complicated with infection group(DMI)(32cases) and diabetes without concurrent infection group(DM)(24cases),besides, non diabetic infection group (NDI)(31cases) and normal control group (N)(25cases) was also chooses,a total of four group,as the research object. All of the subjects were excluded from the primary heart disease, liver disease, kidney disease, malignant tumor, the recent use of immune agents, systemic lupus erythematosus and other immune system function disorder. They were recorded the name, age, course of disease, and other general. All of those were taked4ml fasting blood, the determination of2ml, CD4+, CD8+, CD3+, CD4+/CD8+, B cells, NK cells,2ml determination of IgG, IgM, IgA, C3, C4, recording the results.Results1cell immune indexDMI group, DM group, NDI group compared with N group, the percentage of CD3+cells:the percentage of CD4+cells, CD4+/CD8+cells, B cells, NK cells were decreased (P<0.05),DMI group Compared with DM group, DMI group compared with NDI group: the percentage of CD4+cells, CD4+/CD8+cells, B cells, NK cells were decreased (P <0.05).2humoral immune indicesDMI group, DM group compared with N group:the level of serum IgG were decreased significantly (P<0.05), IgA, complement C3, C4levels were increased(P<0.05), no significant change in IgM (P>0.05).NDI group compared with N group, DMI group compared with DM group: IgA, complement C3, C4levels were increase (P<0.05), IgQ IgM had no significant change (P>0.05).DMI group and compared with NDI group:IgA, C3, C4levels were significantly increased (P<0.05), no significant change in IgG (P>0.05).Conclusionsl.The function of T lymphocyte subsets, B lymphocytes, NK cells, immunoglobulin, complement in Type2diabetes patients is in the equilibrium state.2.The T lymphocyte subsets, B lymphocytes, NK cells, immunoglobulin, complement in patients with type2diabetes mellitus complicated with infection is decreased compared with those without infection, which is prompting that immune dysfunction is an important cause of type2diabetes patients complicated with infection. |
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