Multivariate Analysis Of Prognosis Factors Which Influence The Patients With Glioblastoma Multiforme

Objective: To analyze the affective prognostic parameter in Glioblastoma.Consider revising the theoretical reference for prognosis and treatment of thepatients.Methods: A retrospective study was made about57patients who weretreated for intracranial Glioblastoma Multiforme in the2nd Hospital of HebeiMedical University from Jan.2002to Jan.2012. The medical records of thepatients were reviewed for the age, gander, the preoperative neurologicalstatus defined by the Karnofsky Performance Status (KPS), extent of resection,with or without postoperative radiotherapy and chemotherapy and theexpression of MGMT, PCNA, p53, MMP-9, Ki-67as possible prognosticfactors. The day of operation was used as start points, while the date of deathwas used to establish end points. Operative record and postoperative CT orMRI was adopted to assess the extent of surgery resection. Linear acceleratorradiotherapy and BCNU, Temozolomide, Nimustine, Carmustine wererespectively used for postoperative radiotherapy and chemotherapy. Theexpression of tumor markers was based on pathology department of the2ndHospital of Hebei Medical University. Statistical SPSS19.0software was usedfor Kaplan-Meier method, log-rank test and Multiple Cox Regression toanalyze the date.Results: Following a univariate regression analysis by Kaplan-Meiermethod and log-rank test, lower age, higher preoperative KarnofskyPerformance Scale, total resection, postoperative radiotherapy andchemotherapy were associated with better overall survival rates. MultivariateCox regression analysis showed that age, preoperative Karnofsky PerformanceScale, extent of resection, postoperative radiotherapy and chemotherapy wereindependent prognostic factors influencing survival. The expression of MGMT, PCNA, P53, MMP-9and Ki-67were not revealed to be independentprognostic factors.Conclusion: Combine totally tumor resection with postoperativeradiotherapy and chemotherapy is the main treatment for intracranialGlioblastoma Multiforme. Age and preoperative Karnofsky Performance Scalecan be used to conclude the prognosis of the patients.