Protect Effect And Mechanism Of Baicalin Derivant On Myocardial Ischemia Injury

In this paper, we investigate the protection of baicalin derivant against myocardial ischemia injury and its possible pharmacological mechanism. The acute myocardial ischemia model was made by administration of Pituitrin (Pit) and Isoproterenol (Iso). The results indicated T wave elevation and ST segment drift on electrocardiogram in acute myocardial ischemia rats induced by Pit and Iso were obviously opposed by administration of baicalin derivant. in the myocardial ischemia model induced by Iso, compared with the model group, baicalin derivant could significantly decrease activities of creatine phosphokinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase (AST) in the serum and could decrease the content of malondialdehyd (MDA), increase the activity of the superoxide dismutase (SOD) and Na+-K+-ATPase,Ca2+-Mg2+-ATPase in the myocardial homogenate;the pathohistological changes Iso-induced were also ameliorated. Moreove, acute myocardial ischemia-reperfusion model was performed with left anterior descending (LAD) occlusion in rat heart. The results indicated left ventricular systolic pressure (LVSP), Ventricular pressure maximal change rate (±dp/dtmax) were inereased and myocardial infarction size were reduced by baicalin derivant administration.Summarizing all the experimental results, baicalin derivant could protect against myocardial ischemia injury in the way of enhancing antioxidative potency of the heart, inhibiting lipid peroxidation, ameliorating myocardium energy dysmetabolism and hemodyna-mical indexes and so on.