The Neuropsychological Study On The Memory Monitoirng Of Early Parkinson’s Patients

Objective The aim of this study was to investigate the episodic memory monitoringability in patients with early Parkinson’s disease (PD) and further discuss the potentialmechanism of the episodic memory impairment.Method The feeling-of-knowing (FOK) paradigm were established and subsequentlyadministered in25PD patients and25healthy control (HC) participants who werematched in age and educational level. The R-J-R paradigm have three stages:1.Learning stage:showing the20pairs of words in the center of the computerscreen(15s),20minutes after learning to be recalled;2. Cued recall and FOK judgement:showing the cue word (5s) to let the subjects recalled the target word, and the for FOKjudgments.The answers have six levels, and the1,2,3grade records as a negativejudgment, the4,5,6grade record as the affirmative judgment;3. Recognition stages: thesubjects must the find the target word from six words which is similer with the targetword (5s). The datas will analysis in Goodman－Kruskal correlation analysis, and thevalue of Gamma is the FOK judgment accuracy. Addition, test results will be dividedinto four groups, Rreally Judgment/Rreally Recognition(RR), Really Judgment/FalseRecognition(RF), False Judgment/Really Recognition (FR), False Judgment/FalseRecognition (FF).The RF group is the overestimation group, and the FR group is theunderestimated group.Results Compared with healthy control group, the episodic memory and its monitoringability in early Parkinson’s disease patients were significantly impaired on the accuracy rate of FOK-EMrecall (19.33%±5.10%, t=-4.833, P<0.01), recognition (45.93%±7.82%,t=-2.497, P<0.05) and FOK accuracy (-0.18±0.46, t=-5.986, P<0.01). Furthermore, thecorrect judgment and correct recognition of FOK-EM(20.47%±10.78%) and the correctjudgment and false recognition of FOK-EM(29.53%±5.62%) in the PD group wassignificantly higher than HC group(t=3.564, P<0.05; t=2.306, P<0.05). Most importantly,The stroop effect are positively correlated with the correct judgment and false recognitionof FOK-EMin PD group(r=0.640, P<0.05).Conclusions In present study, the early PD patients demonstrated an overestimation oftheir recognition ability of episodic memory, moreover, this impairment of memorymonitoring was positively related with the deficit of executive function, indicated thatthis mechanism could be an influential factor of memory disorder in early Parkinson’sdisease.