The Influence Of Drug Addict’s Working Memory And Depression On Behavioral Inhibition Explore

There are about100,000--200,000people died from drug addiction every year all over theworld. Drug addiction will not only bring serious damage to drug addicts’ physical and mentalhealth, but will also take catastrophic consequences to the family and social. About drugaddiction, why someone would develop from occasionally use to forced drugging, and onceaddiction, it is so hard to withdraw from the syndrome? Does drug addicts’ cognitive functionhave changed? What about the interaction between cognitive dysfunction and drug addiction’sgeneration, maintain, relapse? The typical symptoms of drug addiction are compulsive drugseeking and relapses behavior, drug addicts loss effective inhibition of drug and it’s related clues,add persistent psychological craving, even after the withdrawal will still appear relapses behavior.It is thus clear that drug addiction is the result of physiological and psychological factors. Thetreatment of drug addiction becomes a worldwide problem, at present, the treatment of opiatesdrug addiction mainly concentrated in drug maintenance therapy (such as methadone、buprenorphine)and psychological therapy, however, drug maintenance therapy will easy toproduce the dependence, and psychological therapy’s long cycle and slow effect result in itslimited application. Therefore, reveal drug addicts’ psychological mechanism of compulsive drugseeking and relapses behavior, explore drug addicts’ cognitive performance damage condition,will bring important practical significance to drug addiction mechanism and its therapy, and willmoreover provide behavior level of evidence for neurological research.At present, there are not many direct research of drug addiction from the view of cognitionand mood, this study from depression and working memory to comprehensive research drugaddicts’ behavioral inhibition function. The results indicated that:1. Drug Addicts’ working memory is impaired, drug addicts’ accuracy of working memoryis higher than healthy non-addicted drug takers. There is no significant difference betweenaddicts’ and non-addicted drug takers’ reaction time.2. Drug Addicts’ depression level is significantly higher than non-addicted drug takers, drugaddicts had depression symptoms accounted for61.36%of the total number of drug addiction.3. Drug Addicts’ behavioral inhibition is impaired, drug addicts’ omission error andreaction time of behavioral inhibition are significantly higher than non-addicted drug takers.4. The accuracy of working memory has significantly influence in the reaction time ofbehavioral inhibition, high working memory testers’ reaction time of behavioral inhibition aresignificantly shorter than low working memory testers. Addiction or not act no significant main effectin behavioral inhibition. The accuracy of working memory has a significant negative correlationwith the omission error and reaction time of behavioral inhibition, and regression effect isobvious.5. Depression level act no significant main effect in behavioral inhibition, addiction or not*depression level have significant mutual effect in the commission error and reaction time ofbehavioral inhibition. Low depression level drug Addicts’ commission error are significantlyhigher than non-addicted drug takers. At low depression level, drug Addicts’ behavioralinhibition are significantly better than non-addicted drug takers. At high depression level,addiction or not have no significant difference in behavioral inhibition, high depression level willreduce behavioral inhibition. Depression has a significant positive correlation with the omissionerror and commission error of behavioral inhibition, but regression effect is indistinctive. 6. Respectively control the depression and working memory as covariant indicate that, theaccuracy of working memory has a more prominent contribution in each index of behavioralinhibition, the damage of working memory will significantly reduce behavioral inhibition,especially the reaction time of behavioral inhibition. Depression has no direct effect in eachindex of behavioral inhibition, addiction or not has different influence in different depressionlevel.