Polyethylene Glycol (peg) - Aspirin Sustained-release Drug Research

Polyethylene glycol, a nontoxic, water-soluble and high hydrophilic polymer, iswidely used in cosmetics, pharmacy, food industries. Aspirin is a non-steroidalanti-inflammatory drug. In the sequential research, people have found it haveeffectiveness to myocardial infarction, thrombosis, cancers, diabetes and some otherdiseases. But for its irritant to the gastric mucosa, the application was widelyrestricted.In order to enhance the efficiency of aspirin and relieve its irritant to the gastricand intestine mucosa, we modified the structure of aspirin via the reaction withpolyethylene glycol. We obtained a series of aspirin derivates and then characterizethem with1H-NMR，FT-IR to verify the structure. Then we studied the slow-releaseproperties in simulated gastric and intestinal fluid. The results indicated thatPEG-aspirin may release at a slow speed in the fluids. The speed increased as thedecreasing molecular weight of PEG. Through the study of synthesis and slow-releaseproperties in vitro, we want to retain the original activity and improve its adversereactions to gastro and intestine. It will provide a base for the study of these seriesdrugs.