Preparation Of Starch-polyvinyl Alcohol Nanofiber Membrane And Its Slow And Control Release Property

This study choose starch as the carrier, aspirin as a model drug, combined with PVA with excellent bio-compatibility, using Electrostatic spinning technique to prepare a drug-loaded fiber with slow and control release capability. This drug-loaded fiber allow a slow and sustained drug release in vivo, make the drug play a stable and efficient role in a certain part, which can address the widespread problems in drug delivery systems such as low drug loading and drug burst. Scanning electron microscopic was used to observe the morphology of the nanofibers, infrared spectroscopy and X- ray diffraction were applied to determine its microstructure, drug content in fiber and cumulative percent release were measured by UV spectrophotometer. The main findings are as follows:1. The concentration of PVA is 4%, 6%, 8%, 10%, 12% is chosed in electrostatic spinning. The results showed that Nanowires spun with PVA concentration at 6%, 8% and 10%.Scanning electron microscopy results showed that nanowire is thinner and have uniform thickness at 8% PVA concentration. It is set to the optimum concentration for the following research.2. Total concentration of ST and PVA was fixed, ration of ST and PVA was adjusted in electrostatic spinning. It was found that when ST / PVA was 1: 2 and 1: 3, uniform nanowires can be obtained. While considering the amount of increase of natural compounds ST, ST / PVA ratio of 1: 2 is selected as optimum ratio for the following research.3. To select the optimum total concentration, total concentration is 8%, 9% and10% in ST / PVA ratio of 1: 2. when the total concentration is greater than 8%, nozzle clogging phenomenon occurs, and nanofiber adhere in electrostatic spinning, so the total concentration is set to 8% for the following research.4. X- ray diffraction results showed that when the drug loading is 1% and 2%, AS characteristic peaks have disappeared, showing a small, round "bread peak", indicating that the surface of the composite nanofiber membranes exhibit amorphous, drugs were wrapped in the fiber. IR spectrum showed that many sharp peaks in the fingerprint region of AS / ST / PVA composite spectrum were weakened or disappeared, indicating that the AS molecules and ST / PVA form a complex through hydrogen bonding.5. Drug release properties were measured by UV spectrophotometer in vitro. Sustained-release effect can be achieved when drug loading was 0.5%, 1.0%, 2.0%. The greater the amount of the drug is, the greater the drug release rate and release amount are. The higher the concentration of starch is, the faster drug release. The greater the pressure is, the slower drug release and drug delivery are, and the longer the time is.