Study Of Aspirin Slow-release In Functional MCM-41

Mesoporous molecular sieve MCM-41 the unique structure characteristics make its application prospect in many field for instance catalysis,adsorption,medicine.This thesis studies the MCM-41 as carrier applied to the Medical slow-release research,overcome to the traditional corrosion inhibitor,because of the obvious deficiencies of the traditional corrosion inhibitor such as unsatisfactory biocompatibility?poor chemical stability?low mechanical strength even with toxicity and other defects.The thesis make used of Hydrothermal synthesis method to synthetic Mesoporous molecular MCM-41 and triblock copolymer CTAB was used as templates and Sodium silicate as silica source.After TMSCl and ATPS as modifier to synthetic CH3-MCM-41 and NH2-MCM-41.The structure and composition of the sieve observed by XRD?IR.The results indicated that Mesoporous material MCM-41 and CH3-MCM-41 and NH2-MCM-41 possess excellent the channel structure,and the structure of Mesoporous molecular sieve was not break in organic modification process.In acidic condition,MCM-41?CH3-MCM-41 and NH2-MCM-41 as carrier material in Slow release system,Aspirin wased connected to Mesoporous materials by esterification recation.The orthogonal experiment method to get the best experimental conditions.The best load conditions is the initial concentration of 80.00%?Temperature of 200?Stirring time of 24 h?Stirring rate of 750 r·min-1.Maximum load factor of MCM-41 to 56.46%?CH3-MCM-4 to 52.83%and NH2-MCM-41 to 50.28%.Study of Mesoporous materials and aspirin sustained release system show that the last release ratio of molecular sieve MCM-41?CH3-MCM-41 and NH2-MCM-41 were 97.52%?93.85%?90.43%after 48 hours respectively.Organic functional group modified MCM-41 slow slower release speed than MCM-41 and Amination modification effect is better than methylation modification.