Research In The Impacting Factors Of Cancer Patients With Picc Catheter Related Infections

OBJECTIVE To determine the incidence and the risk factors for catheter-related infections associated with Peripherally inserted central catheter (PICC) through by the prospective investigation of cancer patients with PICCs. To analyze the category of pathogenic bacterium so as to provide bases for preventing of infections and the reasonable use of antibiotics.METHODS Form October2010to Augrst2011, we collected cancer patients with PICC from the Affiliated Hospital of Qingdao University Medical College. All the patients who met the admission criteria of our study were selected. We recorded the general status and related information when they had their PICCs insertion, maintenance, infections complications. The bacteriologic culture of blood and catheter tip, as well as drug susceptibility testing was performed for the patients who underwent scheduled extubation, and those with catheter related bloodstream infections (CRBSI). The differences in the significance of infections between different groups were examined for statistical significance with chi-square and logistic regression analysis of single and multiple factor was applied for identification of risk factors of PICC related-infections.RESULTS The total dwelling time of373cases cancer patients with PICC was40,547days and the PICC catheter related infection was46cases with the infection rate of1.134per1000catheter-days (12.01%). The patients with location infection of PICC insertion place was37cases with the infection rate of0.913per1000catheter-days (9.66%). The patients with catheter permanent planting bacteria infection of PICC was9cases with the infection rate of0.222per1000catheter-days (2.35%). The patients with catheter related bloodstream infection (CLABSI) was lcase with the infection rate of 0.025per1000catheter-days (0.26%). The pathogenic bacteria causing infections included Coagulase-negative Staphylococci, Staphylococcus epidermidis, Candida sake and Staphylococcus warneri. Logistic regression analysis showed that season, catheter maintenance period, catheter movements and patient’s immunity (P=0.019、0.000,0.000,0.000) were risk factors, and catheter insertion technique (p=0.038) was the protect factor.CONCLUSIONS Increasing the frequency of catheter maintenance in summer, standardization of catheter maintenance and improving patient’s immunity can reduce the rate of PICC catheter related infection.