Amci And Memory In Patients With Ad And The Correlation Of Tcm Syndrome Research

ObjectiveTo investigate memory impairment and Chinese Medicine syndrome characteristics of amnestic mild cognitive impairment (aMCI) and Al-heimer’s disease (AD), and the correlation between the memory impai-rment and Chinese Medicine syndrome, in order to provide evidence for clinical differentiation of syndromes in traditional Chinese Medicine.MethodsTo screen those who were from Dongzhimen Hospital and the surr-onding communities (ages between40and85years old) according to neuropsycholigica1assessments and Chinese Medicine syndrome diffe-rentiation. Diagnosis of AD and aMCI referred to NINCDS-ADRDA’s di-agnostic criteria of AD, and MCI diagnostic criteria reported by PetersenRC in1991.The subjects were subgrouped as normal cognition (NC) group, aMCI group and AD group.Afer basic informations inquiry, neuropsycholigical assessments and Chinese Medicine syndrome diffe-rentiation, the three groups’memory impairment and Chinese Medicine syndrome characteristics will be concluded and the correlation bet-ween thememory impairment and Chinese Medicine syndrome of aMCI and AD will be analysized.Results1.Chinese Medicine syndrome characteristics of aMCI group and AD groupThe percents of syndrome of deficiency of kidney essence, synd-rome of phlegm, syndrome of static blood obstructing brain and syn-drome of hyper activity of yang due to yin deficiency are respecti-vely d i fferent (P=0.003, P=0.000, P=0.015, P=0.020). The prevalence of syndrome of phlegm in AD group (49.1%) and aMCI group (43.2%)are notably higher than NC group (12.2%)(P=0.000, P=0.000). The preva-lence of syndrome of static blood obstructing brain in AD group (44.0%) andaMCI group (37.8%) are notably higher than NC group (22.3%)(P=0.029, P=0.010). The seven Chinese Medicine syndromes’prevalence in aMCI group from top to bottom are syndrome of phlegm, syndrome of static blood obstructing bra in, syndrome of deficiency of kidney essence, syndrome of hyper activity of yang due to yin deficiency, syndrome of deficiency of blood and qi, syndrome of excess of toxic heat, syndrome of viscera stagnation and turbid left, in AD group are syndrome of’phlegm, syndrome of static blood obstructing brain, syndrome of deficiency of kidney essence,syndrome of hyper activity of yang due to yindeficiency, syndrome of deficiency of blood and qi, syndrome of viscerastagnation and turbid left, syndrome of excess of toxic heat. The onsetof aMCI has correlation with syndrome of ph-legm and static blood obstructing brain (P=0.000, P=0.018), while AD with syndrome of deficiency of kidney essence, phlegm, static blood obstructing brain and hyperactivity of yang due to yin defic-iency (P=0.001, P=0.000, P=0.029, P=0.007).2. The correlation between the memory impairment and Chinese Me-dicine syndrome in aMCI and ADAfter control ing age and education, none of MMSE IWR, MMSE DWR, ISR and DSR is correlated with the seven Chinese Medicine syndromes scores in aMCI group. In AD group, MMSE IWR has negativecorrelation with scores of syndrome of static blood obstructing brain (P=0.036). Furthermore, AD patients with syndrome of static blood obs-tructing brain MMSE IWR scores (1.92±1.052) are lower than patients without this syndrome (2.36±0.885)(P=0.030). The subjects with abnormal cognition (CDR>0) MMSE DWR scores has negative correlation with sc-ores of syndrome of phlegm (P=0.038).3. syndrome of phlegm and syndrome of static blood obstructing brain are risk factors to onset of aMC I (P=0.000, P=0.012), while s-yndrome ofphlegm is to AD(P=0.000).Conclusion1. The main Chinese Medicine syndromes in aMCI and AD patients are syndrome of phlegm, syndrome of static blood obstructing brain and syndrome of deficiency of kidney essence. aMCI and AD patients are more easily to get the syndrome of phlegm and syndrome of stat-icblood obstructing brain than NC people.The syndrome of phlegm and syndrome of static blood obstructing brain may have correlation the onset of aMCI and AD.2.Our research find no correlation between memory impairment and Chinese Medicine syndrome in aMCI. MMSE IWR has negative correlati-on with scores of syndrome of static blood obstructing brain in AD. MMSE DWR has negative correlation with scores of syndrome of phlegm in patients with abnormal cognition.3. syndrome of phlegm and syndrome of static blood obstructing brain are risk factors to onset of aMCI, while syndrome of phlegm is to AD.