Insulin-like Growth Factor 1 In The Role Of Spinal Cord Injury Research

Objective:To investigate the neuroprotective effect of insulin-like growth factor1after spinal cord injury, We evaluated the clinical recovery, number of neurons survived, and cell apoptosis after administration of insulin-like growth factor in a rabbit model of spinal cord injury.Methods:24Japanese white rabbits were randomly assigned to receive intravenous injection of either or insulin-like growth factor1. Injury was produced by applying pressure to the spinal cord. Locomotor function were assessed daily using the modified Tarlov’s scale for14days. Spinal cord segments were then harvested and the survival of neurons, and apoptosis were compared among groups.Results:By the end of the second week, neurologic recovery was better in rabbits receiving IGF-1treatment than the control group (p<0.05). Histological study suggested that insulin-like growth factor1treatment not only improved the survival of neurons (p<0.05), but also prevented the apoptosis after spinal cord injury (p<0.05).Conclusions:These results that insulin-like growth factor1provide beneficial effects on neurological recovery after spinal cord injury...